Opioid craving does not incubate over time in inpatient or outpatient treatment studies: Is the preclinical incubation of craving model lost in translation?
Opioid craving does not incubate over time in inpatient or outpatient treatment studies: Is the preclinical incubation of craving model lost in translation?
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DOI：
10.1016/j.neubiorev.2024.105618
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发表时间：
2024-05-01
影响因子：
8.2
通讯作者：
Strickland，Justin C.
中科院分区：
文献类型：
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作者：
Bergeria，Cecilia L.;Gipson，Cassandra D.;Strickland，Justin C.
在成瘾科学中，渴望的孵化是一个操作标签，用于描述在药物剥夺期间寻求药物的时间依赖性增加。本系统综述的目的是描述关于渴望孵化的临床前文献和关于长期禁欲期间测量的渴望的临床文献，以记录这种翻译同源性和影响对应的因素。在符合纳入标准的 44 项临床前研究中，有 31 项报告了证据表明，与较短的禁欲期相比，较长时间的禁欲后，相对于中性隔室，按压杠杆、戳鼻子、舔喷嘴或在药物配对隔室（即寻求药物）中花费的时间更多，被标记为“渴望的孵化”。相比之下，没有临床研究 (n = 20) 发现在较长的戒断期内阿片类药物的渴望会增加。缺乏临床证据证明临床人群渴望增加，削弱了将临床前模型中观察到的药物寻求行为随时间增加作为“渴望”孵化模型的转化效用。
Within addiction science, incubation of craving is an operational label used to describe time-dependent increases in drug seeking during periods of drug deprivation. The purpose of this systematic review was to describe the preclinical literature on incubation of craving and the clinical literature on craving measured over extended periods of abstinence to document this translational homology and factors impacting correspondence. Across the 44 preclinical studies that met inclusion criteria, 31 reported evidence of greater lever pressing, nose pokes, spout licks, or time spent in drug-paired compartments (i.e., drug seeking) relative to neutral compartments after longer periods of abstinence relative to shorter periods of abstinence, labelled as “incubation of craving.” In contrast, no clinical studies (n = 20) identified an increase in opioid craving during longer abstinence periods. The lack of clinical evidence for increases in craving in clinical populations weakens the translational utility of operationalizing the time-dependent increase in drug-seeking behavior observed in preclinical models as models of incubation of “craving”.