Roles of PTEN with DNA Repair in Parkinson's Disease.
Roles of PTEN with DNA Repair in Parkinson's Disease.
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DOI：
10.3390/ijms17060954
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发表时间：
2016-06-15
影响因子：
5.6
通讯作者：
Matsuda S
中科院分区：
文献类型：
--
作者：
Ogino M;Ichimura M;Nakano N;Minami A;Kitagishi Y;Matsuda S
氧化应激被认为在衰老和许多神经退行性疾病如帕金森病的发病机制中起关键作用，其可引起细胞DNA损伤。DNA损伤可导致细胞凋亡，进而导致神经组织变性。最近的证据表明，PTEN（10号染色体上的磷酸酶和张力蛋白同源物）可能参与神经退行性疾病的病理生理。由于PTEN的表达似乎是神经元细胞死亡的一个主要决定因素，因此PTEN应该是治疗帕金森病的新策略的潜在分子靶点。此外，DNA损伤反应和DNA修复的缺陷通常与激素信号通路的调节有关。特别是，许多观察结果暗示雌激素在调节DNA修复作用中的作用。本文从PTEN信号通路和激素对细胞功能调节的角度对DNA修复分子的功能进行了综述，为帕金森病的分子治疗机制提供了一个新的思路。将特别注意提出的机制来解释食品成分对帕金森氏病的健康影响，以减少氧化应激，有效的治疗干预。
Oxidative stress is considered to play key roles in aging and pathogenesis of many neurodegenerative diseases such as Parkinson’s disease, which could bring DNA damage by cells. The DNA damage may lead to the cell apoptosis, which could contribute to the degeneration of neuronal tissues. Recent evidence suggests that PTEN (phosphatase and tensin homolog on chromosome 10) may be involved in the pathophysiology of the neurodegenerative disorders. Since PTEN expression appears to be one dominant determinant of the neuronal cell death, PTEN should be a potential molecular target of novel therapeutic strategies against Parkinson’s disease. In addition, defects in DNA damage response and DNA repair are often associated with modulation of hormone signaling pathways. Especially, many observations imply a role for estrogen in a regulation of the DNA repair action. In the present review, we have attempted to summarize the function of DNA repair molecules at a viewpoint of the PTEN signaling pathway and the hormone related functional modulation of cells, providing a broad interpretation on the molecular mechanisms for treatment of Parkinson’s disease. Particular attention will be paid to the mechanisms proposed to explain the health effects of food ingredients against Parkinson’s disease related to reduce oxidative stress for an efficient therapeutic intervention.