rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population
rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population
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DOI：
10.1016/j.neulet.2014.08.018
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发表时间：
2014-10-03
影响因子：
2.5
通讯作者：
Ling, Wei-Ming
中科院分区：
文献类型：
--
作者：
Gu, Li-Ze;Jiang, Teng;Ling, Wei-Ming
最近的一项全基因组关联研究表明，rs 11098403（NDST 3附近的单核苷酸多态性）与高加索人精神分裂症的风险密切相关。然而，这种关系在其他人群或族裔群体中尚未得到证实。在此，我们进行了一项病例对照研究，以探讨rs 11098403多态性与精神分裂症的风险在中国汉族人群中，包括440名精神分裂症患者和450名对照组。我们首次发现rs 11098403的次要等位基因（G）与精神分裂症的风险降低密切相关（OR = 0.614; 95%CI：0.453-0.833; P = 0.002;把握度= 0.832）。同时，rs 11098403的G等位基因以显性方式降低精神分裂症的危险性（GG + AG vs. AA，OR = 0.526，95% CI：0.374-0.74; P < 0.001）。此外，使用包含267名精神分裂症患者和400名汉族对照者的独立重复样本进一步证实了这种关联（OR = 0.652; 95%CI：0.469-0.907; P = 0.011;把握度= 0.772）。综上所述，这些研究结果表明，rs 11098403和精神分裂症的风险在中国汉族人之间的显着关联，证实了以前从白人获得的数据。(C)2014爱思唯尔爱尔兰有限公司版权所有。
A recent genome-wide association study indicated that rs11098403, a single nucleotide polymorphism in the vicinity of NDST3, was strongly associated with the risk of schizophrenia in Caucasians. However, this relation has not been validated in other populations or ethnic groups. Herein, we conducted a case-control study to investigate the association of rs11098403 polymorphism with the schizophrenia risk in a Han Chinese population comprising 440 schizophrenia patients and 450 control subjects. For the first time, we showed that the minor allele (G) of rs11098403 is closely associated with a reduced risk of schizophrenia (OR = 0.614; 95% CI: 0.453-0.833; P = 0.002; Power = 0.832). Meanwhile, the G allele of rs11098403 seemed to reduce the schizophrenia risk via a dominant manner (GG + AG vs. AA, OR = 0.526; 95% Cl: 0.374-0.74; P < 0.001). Furthermore, this association was further confirmed using an independent replication sample containing 267 schizophrenia patients and 400 control subjects with a Han Chinese descent (OR = 0.652; 95% CI: 0.469-0.907; P = 0.011; Power = 0.772). Taken together, these findings demonstrate a significant association between rs11098403 and schizophrenia risk in Han Chinese, confirming the data that previously obtained from Caucasians. (C) 2014 Elsevier Ireland Ltd. All rights reserved.