Glubran 2®:: A new acrylic glue for neuroradiological endovascular use -: A complementary histological study
Glubran 2®:: A new acrylic glue for neuroradiological endovascular use -: A complementary histological study
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DOI：
10.1177/159101990300900303
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发表时间：
2003-09-01
影响因子：
1.7
通讯作者：
Fini, G
中科院分区：
文献类型：
--
作者：
Leonardi, M;Cenni, P;Fini, G
通过股动脉途径对2头Landrace大型白色猪进行血管造影术。在这2种情况下，通过注射2 ml Glubran 2（R）（用碘油1：1稀释）栓塞上级左肾动脉，从而将上级左肾极排除在血流之外。在随访期间，没有猪出现与栓塞手术相关的任何临床症状。病例1在30天后处死，病例2在60天后处死。对两只动物进行了肉眼和显微镜分析。血管内注射Glubran 2（R）后对两例病例进行了长期随访，结果表明，猪对栓塞手术的临床症状和组织学结果耐受良好。动脉闭塞是稳定的，并且在30至60天之间在缺血组织周围出现了合理数量的瘢痕组织。该后续实验研究提供了进一步的证据，证明Glubran 2（R）就其化学活性而言是一种安全的人用栓塞材料。
Two Landrace Large White swine underwent angiography by the femoral route.In both cases, the superior left renal artery was embolized by injection of 2 ml of Glubran 2(R), diluted with Lipiodol 1:1 thereby excluding the superior left kidney poles from blood flow.During the follow-up period, neither pig presented any clinical symptom correlated to the embolization procedure. Case 1 was sacrificed after 30 days and case 2 after 60 days. Macroscopic and microscopic analysis was performed in both animals.Long-term follow-up of the two cases after endovascular injection of Glubran 2(R) showed that the embolization procedure was well-tolerated by the swine in terms of clinical symptoms and histological findings. Arterial occlusion was stable and a reasonable quantity of scar tissue appeared between 30 and 60 days, surrounding the ischaemic tissue. This follow-up experimental study offers further evidence that Glubran 2(R) is a safe embolizing material for human use as far as its chemical activity is concerned.