Corrigendum to "Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: A cohort study" [Psychoneuroendocrinology 107 (2019) 261-269].
Corrigendum to "Childhood maltreatment, behavioral adjustment, and molecular markers of cellular aging in preschool-aged children: A cohort study" [Psychoneuroendocrinology 107 (2019) 261-269].
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“学龄前儿童的童年虐待、行为调整和细胞衰老的分子标记：队列研究”的勘误表 [Psychoneuroendocrinology 107 (2019) 261-269]。
DOI：
10.1016/j.psyneuen.2019.104466
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发表时间：
2019
影响因子：
3.7
通讯作者：
Tyrka,AudreyR
中科院分区：
文献类型：
--
作者：
Ridout,KathrynK;Parade,StephanieH;Kao,Hung-Teh;Magnan,Stevie;Seifer,Ronald;Porton,Barbara;Price,LawrenceH;Tyrka,AudreyR
目的儿童虐待是导致行为问题和身心健康状况不佳的主要危险因素。通过缩短端粒长度和线粒体功能障碍而加速的细胞衰老可能是这些关联的潜在机制。 方法 在过去六个月内有（n = 133）和没有（n = 123）儿童福利文件记录的中度至重度虐待的家庭参与了这项研究。儿童年龄从 3 岁到 5 岁不等，种族和民族多样化，91% 的儿童有资格获得公共援助。结构化记录审查和访谈用于评估虐待和其他逆境的历史。使用实时 PCR 测量唾液 DNA 的端粒长度和线粒体 DNA 拷贝数 (mtDNAcn)。在六个月的后续评估中重复了这些措施。使用重复测量一般线性模型来检验虐待和其他逆境对端粒长度和 mtDNAcn 随着时间的推移的影响。结果随着时间的推移，虐待和其他不利经历是端粒长度和 mtDNAcn 的显着正向预测因子。内化和外化行为问题也都与端粒长度显着相关，但只有内化症状与 mtDNAcn 相关。结论这是第一项表明 mtDNAcn 在遭受压力和创伤的儿童中发生改变的研究，研究结果与最近的成人研究一致。令人惊讶的是，在过去六个月内经历过中度至重度虐待的儿童的端粒更长，这可能反映了对最近创伤的补偿性变化。端粒长度和 mtDNAcn 也与行为问题相关，这表明这些细胞衰老的测量可能与压力相关疾病的病理生理学有因果关系。
ObjectiveChildhood maltreatment is a major risk factor for the development of behavioral problems and poor physical and mental health. Accelerated cellular aging, through reduced telomere length and mitochondrial dysfunction, may be a mechanism underlying these associations.MethodsFamilies with (n = 133) and without (n = 123) child welfare documentation of moderate-severe maltreatment in the past six months participated in this study. Children ranged in age from 3 to 5 years, were racially and ethnically diverse, and 91% qualified for public assistance. Structured record review and interviews were used to assess a history of maltreatment and other adversities. Telomere length and mitochondrial DNA copy number (mtDNAcn) were measured from saliva DNA using real-time PCR. Measures were repeated at a six-month follow-up assessment. Repeated measures general linear models were used to examine the effects of maltreatment and other adversities on telomere length and mtDNAcn over time.ResultsMaltreatment and other adverse experiences were significant positive predictors of both telomere length and mtDNAcn over time. Internalizing and externalizing behavior problems were also both significantly associated with telomere length, but only internalizing symptoms were associated with mtDNAcn.ConclusionsThis is the first study to show that mtDNAcn is altered in children with stress and trauma, and the findings are consistent with recent studies of adults. Surprisingly, children who experienced moderate-severe levels of maltreatment in the prior six months had longer telomeres, possibly reflecting compensatory changes in response to recent trauma. Telomere length and mtDNAcn were also associated with behavioral problems, suggesting that these measures of cellular aging may be causally implicated in the pathophysiology of stress-related conditions.