Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels
Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels
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DOI：
10.1016/j.atherosclerosis.2007.09.009
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发表时间：
2008-05-01
期刊：
影响因子：
5.3
通讯作者：
Prisco, Domenico
中科院分区：
文献类型：
--
作者：
Sofi, Francesco;Marcucci, Rossella;Prisco, Domenico
视网膜静脉阻塞（RVO）是最常见的视网膜血管疾病之一。在过去的几年里，高水平的同型半胱氨酸 (Hey) 已被证明是 RVO 的独立危险因素。本研究的目的是调查循环 B 族维生素、Hey 和 RVO 之间的关联。因此，我们研究了 262 名 RVO 患者和 262 名年龄和性别相当的健康受试者。通过 HPLC 测定血清维生素 B6，通过放射免疫测定测定血清叶酸和维生素 B12，通过 FPIA 测定血浆 Hcy。发现患者与健康受试者相比，维生素 B6、叶酸和 Hey 的血液水平存在显着差异，但维生素 B12 的水平没有显着差异。在单变量分析中，维生素 B6 的最低三分位数 [比值比 (OR) 4.03； 95%置信区间(0)2.58-6.31； P < 0.0001)]和叶酸（OR 6.13；95% CI 3.85-9.76，P < 0.0001）以及 Hey 的最高三分位数（OR 8.08；95% CI 5.05-12.92，P < 0.0001）被发现与 RVO 显着相关。此外，在多变量分析中，在分别调整传统心血管危险因素Hey和维生素循环水平后，维生素B6（OR 3.29；95% CI 1.89-5.70，P < 0.000 1）和叶酸（OR 5.41；95% CI 3.08-9.51，P < 0.0001）的最低三分位数和Hcy的最高三分位数（OR 2.58；95% CI 1.12-5.94，P < 0.0001）与 RVO 保持显着相关。总之，本研究通过大量患者样本证明，低维生素 B6 水平、低叶酸水平和升高的 Hey 水平均与 RVO 独立相关。 (C) 2007 Elsevier Ireland Ltd. 保留所有权利。
Retinal vein occlusion (RVO) is one of the most common retinal vascular disorders. During the last years, high levels of homocysteine (Hey) have been demonstrated to be an independent risk factor for RVO. Aim of this study was to investigate the association among circulating B-group vitamins, Hey and RVO. Thus, we studied 262 RVO patients and 262 age- and sex-comparable healthy Subjects. Serum vitamin B6 was measured by HPLC, serum folic acid and vitamin B12 by radioimmunoassay and plasma Hcy by FPIA.Blood levels of vitamin B6, folate and Hey, but not of vitamin B12, were found to be significantly different in patients as compared to healthy subjects. At the univariate analysis, the lowest tertile of vitamin B6 [odds ratio (OR) 4.03; 95% confidence interval (0) 2.58-6.31; P < 0.0001)] and folate (OR 6.13; 95% CI 3.85-9.76, P < 0.0001), and the highest tertile of Hey (OR 8.08; 95% CI 5.05-12.92, P < 0.0001) were found to be significantly associated with RVO. Moreover, at multivariate analysis, after adjustment for traditional cardiovascular risk factors, Hey, and circulating levels of vitamins, respectively, the lowest tertile of vitamin B6 (OR 3.29; 95% CI 1.89-5.70, P < 0.000 1) and folate (OR 5.41; 95% CI 3.08-9.51, P < 0.0001) and the highest tertile of Hcy (OR 2.58; 95% CI 1.12-5.94, P < 0.0001) maintained their significant association with RVO. In conclusion, the present study documents, on a large sample of patients, that low vitamin B6 levels, low folic acid levels and elevated Hey levels are each independently associated with RVO. (C) 2007 Elsevier Ireland Ltd. All rights reserved.