Conformational probes for elucidating the nature of substance P binding to the NK1 receptor: initial efforts to map the Phe7-Phe8 region.
Conformational probes for elucidating the nature of substance P binding to the NK1 receptor: initial efforts to map the Phe7-Phe8 region.
复制标题
用于阐明 P 物质与 NK1 受体结合性质的构象探针：绘制 Phe7-Phe8 区域图谱的初步努力。
DOI：
10.1016/s0960-894x(98)00289-3
复制
发表时间：
1998
影响因子：
2.7
通讯作者：
Moeller,KD
中科院分区：
文献类型：
--
作者：
Tong,Y;Fobian,YM;Wu,M;Boyd,ND;Moeller,KD
Three substance P analogs with conformation constraints in the Phe7-Phe8region have been prepared in connection with an effort to differentiate two families of potential conformations for the binding of substance P to its NK1receptor. While the analogs did not bind the NK1receptor with high affinity, the synthesis of the analogs demonstrated the utility of a general method for constructing piperazinone based peptidomimetics.
