Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y.
Sinus and atrioventricular nodal distribution of sympathetic fibers that contain neuropeptide Y.
复制标题
含有神经肽 Y 的交感纤维的窦和房室结分布。
DOI：
10.1161/01.res.67.3.713
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发表时间：
1990
影响因子：
20.1
通讯作者：
Levy,MN
中科院分区：
文献类型：
--
作者：
Warner,MR;Levy,MN
神经肽Y和去甲肾上腺素位于整个心脏的交感神经末梢。我们试图确定含神经肽Y的交感神经纤维在窦和房室结区域的功能分布。我们记录了14只麻醉犬的周期长度、AV间期和动脉压。我们通过测量迷走神经对单侧锁骨下袢刺激后发生的周期长度和AV间期的衰减来评估交感神经末梢释放神经肽Y。三分钟的列车的右或左袢刺激，每个应用在频率为2，5，和10 Hz，产生频率依赖性抑制迷走神经对周期长度和AV间期的影响。然而，在右袢刺激（10 Hz）后，迷走神经效应对周期长度的抑制百分比比迷走神经效应对AV间期的抑制百分比高21 ± 5%（p <0.001）。相反，在左袢刺激（10 Hz）后，迷走神经对AV间期影响的抑制百分比比迷走神经对周期长度影响的抑制百分比高54 +/- 7%（p <0.001）。迷走神经刺激特性（频率或电压）没有显著改变抑制百分比，抑制百分比也不依赖于迷走神经刺激（右或左迷走神经）。我们的结论是，大多数的神经肽Y的交感神经纤维在窦房结起源于右侧神经节，而大多数的AV结起源于左侧神经节。
Neuropeptide Y and norepinephrine are localized in sympathetic nerve terminals throughout the heart. We sought to determine the functional distribution of the neuropeptide Y-containing sympathetic fibers to the sinus and atrioventricular (AV) nodal regions. We recorded cycle length, AV interval, and arterial pressure in 14 anesthetized dogs. We assessed the release of neuropeptide Y from sympathetic nerve terminals by measuring the attenuation of the vagal effects on cycle length and AV interval that occurred after unilateral ansa subclavia stimulation. Three-minute trains of right or left ansa stimulation, each applied at frequencies of 2, 5, and 10 Hz, produced a frequency-dependent inhibition of the vagal effects on cycle length and AV interval. After right ansa stimulation (10 Hz), however, the percent inhibition of the vagal effects on cycle length was 21 +/- 5% greater (p less than 0.001) than the percent inhibition of the vagal effects on AV interval. Conversely, after left ansa stimulation (10 Hz), the percent inhibition of the vagal effects on AV interval was 54 +/- 7% greater (p less than 0.001) than the percent inhibition of the vagal effects on cycle length. The vagal stimulus characteristics (frequency or voltage) did not significantly alter the percent inhibition, nor did the percent inhibition depend on the vagus stimulated (right or left vagus). We conclude that most of the neuropeptide Y-containing sympathetic fibers at the sinus node originate in right-sided ganglia, whereas most of those at the AV node originate in left-sided ganglia.