High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV-related B-cell disease progression in humans
High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV-related B-cell disease progression in humans
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DOI：
10.1182/blood-2010-08-301887
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发表时间：
2011-01-06
期刊：
影响因子：
20.3
通讯作者：
Roger, Michel
中科院分区：
文献类型：
--
作者：
Fontaine, Julie;Chagnon-Choquet, Josiane;Roger, Michel
为了评估树突状细胞 (DC) 对 HIV 相关 B 细胞疾病的可能影响，我们纵向测量了骨髓 DC (mDC) 的 B 淋巴细胞刺激物 (BLyS) 表面表达以及不同疾病进展率的原发性 HIV 感染受试者血液中 B 细胞生长因子的浓度。我们报道，成熟 mDC 和前体的 BLyS 表面表达以及 BLyS、增殖诱导配体 (APRIL)、白细胞介素 6 (IL-6) 和 IL-10 的血液水平在快速和正常 HIV 进展者中均升高至正常水平以上，其速度与感染急性期一样快，并且尽管治疗成功，但在整个病程中仍持续存在。因此，在快速进展者和正常进展者的整个随访过程中，发现高球蛋白血症和循环激活的成熟 B 细胞和前体/激活边缘区 (MZ) 样 B 细胞的高血液水平。相比之下，无病毒血症慢进展者中 BLyS 的 mDC 细胞表面表达以及 BLyS、免疫球蛋白、活化的成熟 B 细胞和前体/活化的 MZ 样 B 细胞的血液水平与健康供体中观察到的相似。有趣的是，进展缓慢者中成熟 MZ B 细胞的水平显着降低。我们的结果表明 DC 可能通过 BLyS 的表达来调节 HIV 相关 B 细胞疾病进展的结果。 （血。2011；117（1）：145-155）
In view of assessing the possible contribution of dendritic cells (DCs) to HIV-related B-cell disorders, we have longitudinally measured B lymphocyte stimulator (BLyS) surface expression by myeloid DCs (mDCs) and concentrations of B-cell growth factors in the blood of subjects undergoing primary HIV infection with different rates of disease progression. We report that BLyS surface expression by mature mDCs and precursors as well as blood levels of BLyS, a proliferation-inducing ligand (APRIL), interleukin-6 (IL-6), and IL-10 increased above normal levels in both rapid and normal HIV progressors as quickly as in the acute phase of infection and persisting throughout the course of disease despite successful therapy. Consequently, hyperglobulinemia and high blood levels of circulating activated mature B cells and precursor/activated marginal zone (MZ)-like B cells were found throughout follow-up for both rapid and normal progressors. In contrast, mDC cell-surface expression of BLyS as well as blood levels of BLyS, immunoglobulin, activated mature B cells, and precursor/activated MZ-like B cells in aviremic slow progressors were similar to those observed in healthy donors. Interestingly, the levels of mature MZ B cells were significantly reduced in slow progressors. Our results suggest that DCs might modulate the outcome of the HIV-related B-cell disease progression through the expression of BLyS. (Blood. 2011;117(1):145-155)