ZincBind-the database of zinc binding sites
ZincBind-the database of zinc binding sites
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DOI：
10.1093/database/baz006
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发表时间：
2019-02-05
影响因子：
5.8
通讯作者：
Martin, Andrew C. R.
中科院分区：
文献类型：
--
作者：
Ireland, Sam M.;Martin, Andrew C. R.
锌是最重要的生物活性金属之一。人类基因组的10%被认为编码一种锌结合蛋白，其用途包括催化、结构稳定、基因表达和免疫。目前，还没有专门的资源来鉴定和呈现所有目前已知的锌结合位点。在这里，我们介绍了ZincBind，一个锌结合位点的数据库及其网络前端。使用蛋白质数据库中的结构数据，ZincBind识别锌与蛋白质结合的每个实例，识别其结合位点，并基于90%的序列同一性对位点进行聚类。目前有24992个结合位点，聚为7489个独特的结合位点。这些数据可以在网络上浏览和下载，也可以通过REST API获得。ZincBind会定期更新，并将继续更新新的数据和功能。
Zinc is one of the most important biologically active metals. Ten per cent of the human genome is thought to encode a zinc binding protein and its uses encompass catalysis, structural stability, gene expression and immunity. At present, there is no specific resource devoted to identifying and presenting all currently known zinc binding sites. Here we present ZincBind, a database of zinc binding sites and its web front-end. Using the structural data in the Protein Data Bank, ZincBind identifies every instance of zinc binding to a protein, identifies its binding site and clusters sites based on 90% sequence identity. There are currently 24 992 binding sites, clustered into 7489 unique sites. The data are available over the web where they can be browsed and downloaded, and via a REST API. ZincBind is regularly updated and will continue to be updated with new data and features.