ZIRCONOCENE COMPLEXES OF UNSATURATED ORGANIC-MOLECULES - NEW VEHICLES FOR ORGANIC-SYNTHESIS
ZIRCONOCENE COMPLEXES OF UNSATURATED ORGANIC-MOLECULES - NEW VEHICLES FOR ORGANIC-SYNTHESIS
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DOI：
10.1126/science.8378769
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发表时间：
1993-09-24
期刊：
影响因子：
56.9
通讯作者：
BUCHWALD, SL
中科院分区：
文献类型：
--
作者：
BROENE, RD;BUCHWALD, SL
过渡金属被认为可以稳定高能量物质，并激活其他不活泼的物质。二茂锆单元稳定高度紧张的炔和烯烃，允许它们用于选择性的碳-碳键形成反应。这个单位还增加了未活化分子的反应性，使它们能够参与非传统的转化。已经开发了一种通用路线，允许更广泛的不饱和片段参与这些反应。这些茂锆配合物在有机合成中的使用导致了许多多官能化有机分子的新途径的发展。
Transition metals are known to stabilize high-energy species and to activate otherwise unreactive ones. The zirconocene unit stabilizes highly strained alkynes and alkenes, allowing their use in selective carbon-carbon bond-forming reactions. This unit also increases the reactivity of unactivated molecules, enabling them to participate in nontraditional transformations. A general route has been developed that allows a wider variety of unsaturated fragments to participate in these reactions. The use of these zirconocene complexes in organic synthesis has led to the development of novel routes to a number of polyfunctionalized organic molecules.