Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.

Advantages of patient-derived orthotopic mouse models and genetic reporters for developing fluorescence-guided surgery.
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DOI:
10.1002/jso.25150
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发表时间:
2018-08
影响因子:
2.5
通讯作者:
Bouvet M
Bouvet M
中科院分区:
医学3区
文献类型:
--
作者:
Lwin TM;Hoffman RM;Bouvet M

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肿瘤引导手术(FGS)可以提高外科医生实现肿瘤完全切除的能力。有许多肿瘤特异性探针正在开发与许多临床前小鼠模型,以评估其疗效。目前的审查讨论了不同的临床前小鼠模型在探针评估的设置,并强调了患者来源的原位(PDOX)小鼠模型和遗传报告的优势,以开发FGS。
Fluorescence-guided surgery (FGS) can enhance the surgeon’s ability to achieve a complete oncologic resection. There are a number of tumor-specific probes being developed with many pre-clinical mouse models to evaluate their efficacy. The current review discusses the different pre-clinical mouse models in the setting of probe evaluation and highlights the advantages of patient-derived orthotopic (PDOX) mouse models and genetic reporters to develop FGS.
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