A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population
A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population
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DOI：
10.1007/s12263-015-0502-2
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发表时间：
2015-11-01
影响因子：
3.5
通讯作者：
Friedlander, Yechiel
中科院分区：
文献类型：
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作者：
Dorajoo, Rajkumar;Sun, Ye;Friedlander, Yechiel
多不饱和脂肪酸（PUFA）对人类健康具有重大影响。最近的全基因组关联研究 (GWAS) 已在主要欧洲血统受试者中确定了几个与 n-3 和 n-6 PUFA 血浆水平相关的遗传位点。然而，这些发现的相关性尚未在其他种族群体中得到广泛评估。本研究的主要目的是评估与 n-3 和 n-6 PUFA 相关的遗传位点，并使用新加坡华人群体的数据验证最近确定的索引位点的作用。使用 GWAS 方法，我们评估了三种 n-3 PUFA [α-亚麻酸 (ALA)、二十碳五烯酸和二十二碳六烯酸]、四种 n-6 PUFA [亚油酸 (LA)、γ-亚麻酸、二高γ-亚麻酸 (DGLA) 和花生四烯酸] 与血浆浓度的关联，并估计了 新加坡华人健康研究参与者 (N = 1361) 的 delta-5 去饱和酶和 delta-6 去饱和酶活性。我们的结果揭示了强大的全基因组关联（p 值
Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6 PUFAs in primarily subjects of European ancestry. However, the relevance of these findings has not been evaluated extensively in other ethnic groups. The primary aim of this study was to evaluate for genetic loci associated with n-3 and n-6 PUFAs and to validate the role of recently identified index loci using data from a Singaporean Chinese population. Using a GWAS approach, we evaluated associations with plasma concentrations of three n-3 PUFAs [alphalinolenic acid (ALA), eicosapentaenoic acid and docosahexaenoic acid], four n-6 PUFAs [linoleic acid (LA), gammalinolenic acid, dihomogammalinolenic acid (DGLA) and arachidonic acid], and estimates of delta-5 desaturase and delta-6 desaturase activities among the participants (N = 1361) of the Singaporean Chinese Health Study. Our results reveal robust genome-wide associations (p value