Clinical and Echocardiographic Characteristics of Papillary Fibroelastomas: A Retrospective and Prospective Study in 162 Patients
Clinical and Echocardiographic Characteristics of Papillary Fibroelastomas: A Retrospective and Prospective Study in 162 Patients
复制标题
乳头状纤维弹性瘤的临床和超声心动图特征：162 例患者的回顾性和前瞻性研究
作者：
J. Sun;C. Asher;X. Yang;Georgiana Cheng;G. Scalia;AnMalek G. Massed;B. Griffin;N. Ratliff;W. Stewart;James D. Thomas
背景——心脏乳头状弹力纤维瘤（CPF）是一种原发性心脏肿瘤，越来越多地通过超声心动图检测到。该实体的临床表现尚未得到很好的描述。方法和结果——在 16 年的时间里，我们从病理学和超声心动图数据库中识别出了 CPF 患者。共有162名患者经病理证实有CPF。对 141 名具有 158 个 CPF 的患者进行了超声心动图检查，其中 48 名患者的 CPF 超声心动图不可见（<0.2 cm），剩下 93 名具有 110 个 CPF 的患者组成的超声心动图亚组。另外确定了 45 名推测诊断为 CPF 的患者。患者平均年龄为60±16岁，其中46.1%为男性。超声心动图显示，CPF 的平均大小为 9±4.6 mm； 82.7% 发生在瓣膜上（主动脉多于二尖瓣），43.6% 为活动瓣，91.4% 为单一瓣。在11±22个月的随访期间，经病理检查证实的26名前瞻性诊断为CPF的患者中，有23名患者出现了可能归因于栓塞的症状。在 45 名推定诊断为 CPF 的患者中，3 名患者在 552±706 天的随访期间出现了可能由栓塞引起的症状（发生率为 6.6%）。结论：CPF 通常较小且单一，最常发生在瓣膜表面，并且可能会移动，导致栓塞。由于存在发生栓塞事件的可能性，有症状的患者、因其他病变而接受心脏手术的患者以及具有高活动性和大 CPF 的患者应考虑手术切除。
Background—Cardiac papillary fibroelastoma (CPF) is a primary cardiac neoplasm that is increasingly detected by echocardiography. The clinical manifestations of this entity are not well described. Methods and Results—In a 16-year period, we identified patients with CPF from our pathology and echocardiography databases. A total of 162 patients had pathologically confirmed CPF. Echocardiography was performed in 141 patients with 158 CPFs, and 48 patients had CPFs that were not visible by echocardiography (<0.2 cm), leaving an echocardiographic subgroup of 93 patients with 110 CPFs. An additional 45 patients with a presumed diagnosis of CPF were identified. The mean age of the patients was 60±16 years of age, and 46.1% were male. Echocardiographically, the mean size of the CPFs was 9±4.6 mm; 82.7% occurred on valves (aortic more than mitral), 43.6% were mobile, and 91.4% were single. During a follow-up period of 11±22 months, 23 of 26 patients with a prospective diagnosis of CPF that was confirmed by pathological examination had symptoms that could be attributable to embolization. In the group of 45 patients with a presumed diagnosis of CPF, 3 patients had symptoms that were likely due to embolization (incidence, 6.6%) during a follow-up period of 552±706 days. Conclusions—CPFs are generally small and single, occur most often on valvular surfaces, and may be mobile, resulting in embolization. Because of the potential for embolic events, symptomatic patients, patients undergoing cardiac surgery for other lesions, and those with highly mobile and large CPFs should be considered for surgical excision.
心脏乳头状弹力纤维瘤引起的栓塞性中风。
影响因子：
8.3
作者：
Kasarskis,EJ;O'Connor,W;Earle,G
通讯作者：
Earle,G