N-methyl-N'-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation.
N-methyl-N'-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation.
复制标题
N-甲基-N-硝基-N-亚硝基胍诱导的电离辐射抗性。
DOI：
10.1007/bf00333577
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Smith,DS
中科院分区：
文献类型：
--
作者：
Morse,ML;Smith,DS
n -甲基-n ' -硝基-n -亚硝基胍（MNNG）预处理提高了大肠杆菌γ辐射的抗性。增加的抗性依赖于功能性的pola、recA、recB、recC和lexAgenes，部分依赖于recn。mnng诱导的抗性是γ-辐射预处理诱导的抗性的附加性，而不是过氧化氢诱导的抗性增加。MNNG诱导的耐药发生在不适应应答剂和预处理水平的MNNG，这些MNNG不能激活细胞重新激活紫外线灭活的lambda噬菌体。mnng诱导的电阻似乎不同于其他诱导的γ辐射电阻。
N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) pretreatments increase the resistance ofEscherichia colito γ-radiation. The increased resistance is dependent on functionalpolA, recA, recB, recC, and lexAgenes and is partly dependent onrecN. The MNNG-induced resistance is additive to resistance induced by pretreatment with γ-radiation but not by increases induced by hydrogen peroxide. The MNNG-induced resistance occurs inadaptive responsemutants and at pretreatment levels of MNNG that do not activate cells to reactivate UV-inactivated lambda phage. The MNNG-induced resistance appears to be distinct from other inductions to γ-radiation resistance.