Chemoselective control of hydrogenation among aromatic carbonyl and benzyl alcohol derivatives using Pd/C(en) catalyst
Chemoselective control of hydrogenation among aromatic carbonyl and benzyl alcohol derivatives using Pd/C(en) catalyst
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DOI：
10.1016/s0040-4020(01)00421-5
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发表时间：
2001-06-04
期刊：
影响因子：
2.1
通讯作者：
Hirota, K
中科院分区：
文献类型：
--
作者：
Hattori, K;Sajiki, H;Hirota, K
芳香酮和醛在Pd/C催化剂作用下氢解生成中间体苯甲醇，生成相应的亚甲基化合物。因此，选择性地分离中间体苯甲醇是非常困难的。本文介绍了在10%Pd/C(En)催化剂上，芳香族羰基化合物温和的化学选择性加氢合成苯甲醇的方法及其在苯甲醇官能团存在下的苯位化学选择性脱乙酰氧基化反应中的应用。(C)2001爱思唯尔科学有限公司。保留所有权利。
The hydrogenolysis of aromatic ketones and aldehydes quite smoothly give the corresponding methylene compounds via the formation of the intermediary benzyl alcohols in the presence of Pd/C as a catalyst. Therefore, it is extremely difficult to isolate the intermediary benzyl alcohol selectively. This paper describes a mild and chemoselective hydrogenation method of an aromatic carbonyl compound to benzyl alcohol using the 10% Pd/C(en) catalyst and its application to the chemoselective deacetoxylation reaction at the benzylic position in the presence of the benzyl alcohol functionality within the molecule. (C) 2001 Elsevier Science Ltd. All rights reserved.