Biological Basis of Depression in Adults with Diabetes
Biological Basis of Depression in Adults with Diabetes
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DOI：
10.1007/s11892-010-0148-9
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发表时间：
2010-12-01
影响因子：
4.2
通讯作者：
Golden, Sherita Hill
中科院分区：
文献类型：
--
作者：
Champaneri, Shivam;Wand, Gary S.;Golden, Sherita Hill
糖尿病和抑郁症是常见的并存疾病。虽然某些健康行为和风险因素部分解释了抑郁症和糖尿病之间的联系，但其他潜在的机制尚未阐明。某些神经内分泌改变，如下丘脑-垂体-肾上腺(HPA)轴和交感神经系统(SNS)的激活可能有助于这种联系。此外，最近文献中显示的糖尿病和抑郁症的促炎状态也可能与此有关。这篇综述的目的是总结和回顾最近的证据，这些证据表明在抑郁症、糖尿病和糖尿病相关的危险因素中，这三个生物系统--HPA轴、SNS和炎症级联系统发生了变化。
Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.