NEURAL CONTROL OF URETHRAL OUTLET ACTIVITY IN-VIVO - ROLE OF NITRIC-OXIDE
NEURAL CONTROL OF URETHRAL OUTLET ACTIVITY IN-VIVO - ROLE OF NITRIC-OXIDE
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DOI：
10.1016/s0022-5347(01)67391-9
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发表时间：
1995-06-01
影响因子：
6.6
通讯作者：
DEGROAT, WC
中科院分区：
文献类型：
--
作者：
BENNETT, BC;KRUSE, MN;DEGROAT, WC
本研究探讨了一氧化氮（NO）在排尿时尿道出口活动反射性变化中的作用。等容膀胱收缩，尿道压力和尿道外括约肌肌电图（EUS EMG）活动独立记录在麻醉大鼠。在反射性膀胱收缩期间，尿道表现出反射性反应，其特征在于尿道压力的初始降低与膀胱压力的升高相结合。随后是一段与最大尿道松弛和爆发型EUS EMG活动相关的高频振荡（HFO）。给予N-硝基-L-精氨酸（L-NOARG）10 mg。/ kg.静脉注射一氧化氮合酶抑制剂，可逆地降低了幅度（62%，p
The present study investigated the role of nitric oxide (NO) in the reflex changes in urethral outlet activity during micturition. Isovolumetric bladder contractions, urethral pressure and external urethral sphincter electromyogram (EUS EMG) activity were recorded independently in urethane-anesthetized rats. During reflex bladder contractions, the urethra exhibited reflex responses characterized by an initial decrease in urethral pressure in conjunction with a rise in bladder pressure. This was followed by a period of high frequency oscillations (HFOs) associated with maximal urethral relaxation and burst type EUS EMG activity. Administration of N-nitro-L-arginine (L-NOARG) 10 mg./kg. intravenously, a nitric oxide synthase inhibitor, reversibly decreased the magnitude (62%, p