Role of phosphatase and tensin homolog in the development of the mammalian auditory system
Role of phosphatase and tensin homolog in the development of the mammalian auditory system
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DOI：
10.1097/wnr.0b013e32833bfb5e
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发表时间：
2010-07-14
期刊：
影响因子：
1.7
通讯作者：
Tokuda, Masaaki
中科院分区：
文献类型：
--
作者：
Dong, Youyi;Sui, Li;Tokuda, Masaaki
磷酸酶和张力蛋白同源基因(PTEN)是一种肿瘤抑制基因，控制神经干细胞的更新和分化，是视神经再生的潜在靶点。在这里，我们证明了它在哺乳动物发育中的听觉系统中有一个关键的表达模式。胚胎10.5天时，PTEN在耳蜗神经节开始表达，之后随着毛细胞从耳蜗基底部向耳蜗尖的分化，PTEN的表达逐渐增强。出生后第7天，PTEN在毛细胞中下调，随后在神经元中下调。这种非常特异的瞬时表达模式表明，PTEN在感觉神经元和毛细胞的分化中起着至关重要的作用，它是一个潜在的听力再生的治疗靶点。神经报告21：731-735(C)2010沃尔特斯·克鲁沃健康垂直酒吧Lippincott Williams&Wilkins。
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene that controls neural stem cell renewal and differentiation and is a potential target for regeneration in the optic nerve. Here we show that it has a critical pattern of expression in the mammalian developing auditory system. PTEN was expressed in the cochlear-vestibular ganglion at embryonic day 10.5 and then progressively in hair cells as they differentiated from the base to the apex of the cochlea. By postnatal day 7, PTEN was downregulated in hair cells and subsequently in the neurons. This very specific, transient expression pattern suggests that PTEN plays a crucial role in the differentiation of the sensory neurons and hair cells and that it is a potential therapeutic target for hearing regeneration. NeuroReport 21:731-735 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.