Bordetella holmesii-like organisms associated with septicemia, endocarditis, and respiratory failure
Bordetella holmesii-like organisms associated with septicemia, endocarditis, and respiratory failure
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DOI：
10.1086/516323
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发表时间：
1998-02-01
影响因子：
11.8
通讯作者：
Persing, DH
中科院分区：
文献类型：
--
作者：
Tang, YW;Hopkins, MK;Persing, DH
我们从三名败血症、心内膜炎和/或呼吸衰竭患者的血液或痰中回收了一种不寻常的细菌菌株。这三个菌株是薄的，弯曲的，革兰氏阴性，浅棕色，产色素与可变过氧化氢酶活性的杆菌。它们是溶砷的、氧化酶阴性的、不运动的和挑剔的。仅根据这些特征或结合细胞脂肪酸谱进行鉴别是不可能的。16 S rRNA基因的核酸扩增和序列分析显示，所有三个分离株是相同的，最密切相关的新兴病原体霍氏博德特氏菌，偏离公布的序列在三个核苷酸的位置（99.8%的相似性）。分离出一个B。来自痰的类霍氏杆菌病原体表明，除了产生败血症之外，该生物体可以像其他博德特氏菌属物种一样栖息在呼吸道中。
We recovered an unusual bacterial strain from blood or sputum of three patients with septicemia, endocarditis, and/or respiratory failure. The three isolates were thin, curved, gram-negative, light brown, pigment-producing bacilli with variable catalase activity. They were asaccharolytic, oxidase-negative, nonmotile, and fastidious. Identification was not possible on the basis of these characteristics alone or in combination with cellular fatty acid profiles. Nucleic acid amplification and sequence analysis of the 16S rRNA gene revealed that all three isolates were identical and most closely related to the emerging pathogen Bordetella holmesii, diverging from the published sequence at three nucleotide positions (99.8% similarity). Isolation of a B. holmesii-like pathogen from sputum suggests that, in addition to producing septicemia, the organism may inhabit the respiratory tract like other Bordetella species.