Continuous-time control of alternans in long Purkinje fibers
Continuous-time control of alternans in long Purkinje fibers
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DOI：
10.1063/1.4893295
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发表时间：
2014-09-01
期刊：
影响因子：
2.9
通讯作者：
Fenton, Flavio H.
中科院分区：
文献类型：
--
作者：
Garzon, Alejandro;Grigoriev, Roman O.;Fenton, Flavio H.
交替——心脏组织对周期性起搏的一种心律失常反应——通常是更危险、甚至可能致命的颤动状态的前兆。使用反馈控制抑制奥特那可能是预防纤维性颤动的可行方法。之前已经提出了几种基于脉冲控制的方法，其中在每个起搏间隔期间的短暂时间内应用反馈。本文提出了一种连续时间方法，其中始终施加反馈电流，与脉冲控制（小于 1 厘米）相比，该方法能够抑制长度明显更长（长达至少 4 厘米）的纤维中的交替，并且适用于各种起搏周期长度。 (C) 2014 AIP 出版有限责任公司。
Alternans-an arrhythmic response of cardiac tissue to periodic pacing-often serves as a precursor to a more dangerous, and potentially lethal, state of fibrillation. Suppression of alternans using feedback control may be a plausible method to prevent fibrillation. Several approaches based on impulsive control have been proposed previously, where feedback is applied for a brief instance of time during each pacing interval. This paper presents a continuous-time approach, where feedback current is applied at all times, which is capable of suppressing alternans in fibers of significantly greater length (up to at least 4 cm), compared with impulsive control (less than 1 cm), and for a wide range of pacing cycle lengths. (C) 2014 AIP Publishing LLC.