GENETIC AND PHYSIOLOGICAL-PARAMETERS ASSOCIATED WITH CADMIUM TOXICITY IN DROSOPHILA-MELANOGASTER
GENETIC AND PHYSIOLOGICAL-PARAMETERS ASSOCIATED WITH CADMIUM TOXICITY IN DROSOPHILA-MELANOGASTER
复制标题
DOI：
10.1007/bf00504291
复制
发表时间：
1985-01-01
影响因子：
2.4
通讯作者：
JACOBSON, KB
中科院分区：
文献类型：
--
作者：
CHRISTIE, NT;WILLIAMS, MW;JACOBSON, KB
两种黑腹果蝇菌株对 CdCl2 的致死作用具有极端的抵抗力和敏感性。含有突变朱红色和棕色 (v;bw) 的菌株以及奥斯汀菌株的 LC50 值分别为 3.3 和 1.3 mM CdCl2。这两个菌株的三个主要染色体在遗传上分为六种可能的组合。这六种基因型的 CdCl2 测量 LC50' 根据 X 染色体分为两组；那些含有来自 v 的 X 染色体； bw 的 LC50 比 X 染色体来自 Austin 的那些高 0.5-1.0 mM。由于亲本菌株相差 2 mM，我们认为 X 染色体是产生 CdCl2 抗性的基因的主要位点，但不是唯一的位点。当饮食中含有 109Cd 时，v 的吸收量； bw 和奥斯汀 2 天都是一样的。摄取 4 天后，Austin 菌株排泄 109Cd 的速度是 v 的五倍； bw，但六种基因型彼此之间的排泄率没有明显差异，并且与敏感亲本 Austin 的相似度高于抗性亲本。因此，表明了第二个过程，该过程区分了显然与 X 染色体无关的 CdCl2 抗性。
Two strains of Drosophila melanogaster represent the extremes in resistance and sensitivity to the lethal effects of CdCl2. The strain containing the mutations vermilion and brown (v;bw) and the strain Austin had LC50''s of 3.3 and 1.3 mM CdCl2, respectively. The three major chromosomes from these two strains were assorted genetically into the six possible combinations. The measured LC50''s for CdCl2 for these six genotypes fell into two groups according to the X chromosome; those containing the X chromosome from v; bw had LC50''s 0.5-1.0 mM greater than those in which the X chromosome was from Austin. Since the parent strains differed by 2 mM, we suggest that the X chromosome is a major, but not the sole, site of genes to produce resistance to CdCl2. When 109Cd was in the diet the uptake by v; bw and Austin over 2 days was the same. After 4 days of uptake, the Austin strain excreted the 109Cd five times faster than v; bw but the six genotypes did not differ appreciably in excretion rate from one another and resembled the sensitive parent Austin more than the resistant one. Thus a second process is indicated that distinguishes resistance to CdCl2 that apparently is not associated with the X chromosome.