Acute reductions in GABAA receptor binding in layer IV of adult primate somatosensory cortex after peripheral nerve injury.
Acute reductions in GABAA receptor binding in layer IV of adult primate somatosensory cortex after peripheral nerve injury.
复制标题
周围神经损伤后，成年灵长类体感皮层 IV 层 GABAA 受体结合急剧减少。
DOI：
10.1016/s0006-8993(02)03343-7
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发表时间：
2002
期刊：
影响因子：
2.9
通讯作者：
Garraghty,PE
中科院分区：
文献类型：
--
作者：
Wellman,CL;Arnold,LL;Garman,EE;Garraghty,PE
Following peripheral nerve transection, reorganizational plasticity has been reported to occur in two phases, one immediate and one more protracted. GABA (γ-aminobutyric acid) has been implicated in the immediate ‘unmasking’ phase of reorganization. We have used quantitative autoradiography to assess potential changes in GABAAand GABABreceptor binding in primate somatosensory cortex following peripheral nerve injury. Here we report reductions in GABAAreceptor binding in layer IV of primate somatosensory cortex deprived of its normal activating inputs for 2–5 h by peripheral nerve transection.
