FUNCTIONAL-CHARACTERIZATION OF PREGANGLIONIC NEURONS PROJECTING IN THE LUMBAR SPLANCHNIC NERVES - VASOCONSTRICTOR NEURONS
FUNCTIONAL-CHARACTERIZATION OF PREGANGLIONIC NEURONS PROJECTING IN THE LUMBAR SPLANCHNIC NERVES - VASOCONSTRICTOR NEURONS
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DOI：
10.1016/0165-1838(86)90009-3
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发表时间：
1986-02-01
期刊：
影响因子：
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通讯作者：
JANIG, W
中科院分区：
文献类型：
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作者：
BAHR, R;BARTEL, B;JANIG, W
腰椎神经节前神经元投射在腰椎内脏神经上，可能具有血管收缩功能（内脏血管收缩，VVC神经元），对其放电模式进行了分析。这些神经元对下列自然刺激的反应被测试：动脉压力感受器、动脉化学感受器和来自膀胱、结肠和肛门粘膜皮肤的内脏传入的刺激。49个神经节前神经元归为VVC神经元。它们表现出以下特征：(1)VVC神经元的持续活动表现出明显的心律失常，并与人工通气周期相关。血压升高或孤立颈动脉盲囊内压力升高引起的动脉压力感受器的刺激导致VVC神经元活性的抑制。血压降低引起的动脉压力感受器卸荷导致VVC神经元活动增加。(2)在颈动脉血管小球附近，通过大量注射富含二氧化碳的生理盐水刺激动脉化学感受器，导致VVC神经元的弱兴奋。全身缺氧对动脉化学感受器的刺激导致VVC神经元的弱兴奋和/或活性抑制。(3)膀胱和结肠等体积收缩和扩张的内脏传入刺激对大多数VVC神经元没有影响。肛门刺激也没有引起大多数VVC神经元的反射。(4)约14%的VVC神经元（49个中的7个）被至少一种内脏刺激激活，其方式与运动调节（MR）神经元相同（见参考1）。(5)这项研究表明，可能参与结肠盆腔器官血管阻力调节的节前神经元在功能上是一种独特的神经元群体，与运动调节神经元有一些有趣的功能重叠（见参考1）。
Lumbar preganglionic neurons, which project in the lumbar splanchnic nerves and which probably have a vasoconstrictor function (visceral vasoconstrictor, VVC neurons), were analyzed for their discharge patterns. The responses of these neurons to the following natural stimuli were tested: stimulation of arterial baroreceptors, arterial chemoreceptors and visceral afferents from the urinary bladder, the colon and the mucosal skin of the anus. Forty-nine preganglionic neurons were classified as VVC neurons. They showed the following characteristics: (1) the ongoing activity of the VVC neurons exhibited pronounced cardiac rhythmicity and correlated with the cycle of the artificial ventilation. Stimulation of arterial baroreceptors, produced by increase of blood pressure or by increase of pressure in an isolated carotid blind sac, led to inhibition of activity in VVC neurons. Unloading of arterial baroreceptors, produced by decrease of blood pressure, led to an increase in VVC neuron activity. (2) Stimulation of arterial chemoreceptors by bolus injections of CO2-enriched saline solution, close to a carotid glomus, led to a weak excitation of VVC neurons. Stimulation of arterial chemoreceptors by systemic hypoxia led to weak excitation and/or to depression of activity in VVC neurons. (3) Stimulation of visceral afferents from urinary bladder and colon by isovolumetric contractions and distensions of the organs had no effect on most VVC neurons. Anal stimulation also did not induce reflexes in the majority of the VVC neurons. (4) Some 14% of the VVC neurons (7 from 49) were excited by at least one of the visceral stimuli in the same manner as the motility-regulating (MR) neurons (see ref. 1). (5) This investigation shows that preganglionic neurons, probably involved in regulation of vascular resistance in colon pelvic organs, are functionally a distinct population of neurons with some interesting functional overlap with the motility-regulating neurons (see ref 1).