TUMOR-INDUCED OSTEOMALACIA
TUMOR-INDUCED OSTEOMALACIA
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DOI：
10.1016/s0049-0172(95)80016-6
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发表时间：
1995-08-01
影响因子：
5
通讯作者：
BEST, LA
中科院分区：
文献类型：
--
作者：
SCHAPIRA, D;BENIZHAK, O;BEST, LA
肿瘤诱发（致癌）骨软化症是一种罕见的临床病理实体，其中骨软化症的临床体征和症状以及低磷血症、高磷酸盐尿和低血清 1,25(OH)(2) 维生素 D 水平低等特定实验室异常与患者肿瘤过程的发现相关。迄今为止，已知的致癌性骨软化症病例还不到 100 例。我们报告了一例成人发病的低磷血症性骨软化症的新病例，导致发现无症状的磷酸盐性间叶性肺肿瘤。完全切除肺肿瘤后，实验室检查结果迅速正常化，临床缓解。介绍了肿瘤引起的骨软化症的临床、实验室和组织病理学谱，并根据相关文献讨论了这种情况的假设机制。对于无法解释的成人骨软化症，应考虑隐匿性肿瘤的存在，切除肿瘤后医生的努力得到了显着治愈的回报。 (C) 1995 年，W.B.桑德斯公司
Tumor-induced (oncogenic) osteomalacia is a rare clinicopathologic entity in which the clinical signs and symptoms of osteomalacia and the specific laboratory abnormalities of hypophosphatemia, hyperphosphaturia, and low serum levels of 1,25(OH)(2) vitamin D are associated with the finding of a neoplastic process in the patient. To date, less than 100 cases of oncogenic osteomalacia have been described. We report a new case of adult-onset hypophosphatemic osteomalacia leading to the discovery of an asymptomatic phosphaturic mesenchymal lung tumor. Complete resection of the pulmonary neoplasia was followed by rapid normalization of the laboratory findings and clinical remission. The clinical, laboratory, and histopathologic spectrum of tumor-induced osteomalacia is presented, and the postulated mechanism of this condition is discussed in light of the relevant literature. The presence of occult neoplasms should be considered in cases of unexplained adult osteomalacia, with the physician's efforts being rewarded by the dramatic cure that follows excision of the tumor. (C) 1995 by W.B. Saunders Company