IGF-1 Partially Restores Chemotherapy-Induced Reductions in Neural Cell Proliferation in Adult C57BL/6 Mice
IGF-1 Partially Restores Chemotherapy-Induced Reductions in Neural Cell Proliferation in Adult C57BL/6 Mice
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DOI：
10.3109/07357900903405942
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发表时间：
2010-06-01
影响因子：
2.4
通讯作者：
Gross, Robert A.
中科院分区：
文献类型：
--
作者：
Janelsins, Michelle C.;Roscoe, Joseph A.;Gross, Robert A.
化学药剂通过一种未知的机制在记忆中产生持续的困难。我们测试的假设，化疗药物容易能够通过血脑屏障（环磷酰胺和氟尿嘧啶），而不是那些不知道容易通过屏障（紫杉醇和阿霉素），减少化疗后神经细胞增殖。我们发现，5-溴-2-脱氧尿苷标记化疗后给予C57 BL/6小鼠显示了类似的减少在齿状回的神经细胞增殖的所有四个代理商。胰岛素样生长因子1，一种促进神经发生的分子，抵消了高剂量化疗对神经细胞增殖的影响。
Chemotherapeutic agents produce persistent difficulties in memory through an unknown mechanism. We tested the hypothesis that chemotherapeutic agents readily able to cross the blood-brain barrier (cyclophosphamide and fluorouracil), as opposed to those not known to readily cross the barrier (paclitaxel and doxorubicin), reduce neural cell proliferation following chemotherapy. We found that 5-bromo-2-deoxyuridine labeling following chemotherapy given to C57BL/6 mice revealed a similar reduction in neural cell proliferation in the dentate gyrus for all four agents. Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation.