Features and outcomes of lupus nephritis in Morocco: analysis of 114 patients.
Features and outcomes of lupus nephritis in Morocco: analysis of 114 patients.
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DOI：
10.2147/ijnrd.s34299
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发表时间：
2013
影响因子：
2
通讯作者：
Bayahia R
中科院分区：
文献类型：
--
作者：
Haddiya I;Hamzaoui H;Tachfouti N;Hamany ZA;Radoui A;Zbiti N;Amar Y;Rhou H;Benamar L;Ouzeddoun N;Bayahia R
狼疮性肾炎（LN）的临床表现和预后在不同民族之间存在很大差异。关于北非人，尤其是摩洛哥人的LN数据很少。我们研究的目的是回顾摩洛哥LN患者的特征和预后。我们进行了一项单中心回顾性研究。共纳入114例LN患者。所有患者均符合美国风湿病协会的标准。LN按照国际肾脏病学会/肾脏病理学会分类进行分类。我们采用先前定义的LN预后标准。女性101例，男性13例，平均年龄29.9岁。首次出现时，我们注意到33%的患者有高血压，76%的患者有血尿，53%的患者有肾病综合征，60%的患者有肾衰竭。肾活检显示超过80%的患者有明显的增生性。患者接受以静脉注射环磷酰胺为主的不同治疗方案。平均随访22个月后，缓解率为45.5%，复发率为82%，终末期肾衰竭率为21%，死亡率为16%。感染、神经系统和心血管疾病是最常见的死亡原因。在我们的研究中，LN似乎是严重的，以增生性形式为主，肾脏表现严重，肾脏和总体生存期较差。
There is wide variation in clinical presentation and outcome of lupus nephritis (LN) among different ethnic groups. Few data for LN exist on North Africans, especially those from Morocco. The aim of our study was to review retrospectively the features and outcome of LN in Moroccan patients. We performed a single-center retrospective study. A total of 114 patients with LN were included. All patients met American Rheumatism Association criteria. LN was classified according to the International Society of Nephrology/Renal Pathology Society classification. We adopted previously defined outcome criteria for LN. There were 101 females and 13 males, with a mean age of 29.9 years. At first presentation, we noted hypertension in 33%, hematuria in 76%, nephrotic syndrome in 53%, and renal failure in 60% of cases. Renal biopsy revealed predominant proliferative classes in more than 80% of patients. Patients received different regimens mainly based on intravenous cyclophosphamide. After a mean follow-up of 22 months, remission occurred in 45.5%, relapses in 82%, end-stage renal failure in 21%, and death in 16% of cases. Infection and neurological and cardiovascular diseases were the most frequent causes of death. LN seems to be severe in our study, with a predominance of proliferative forms, severe renal manifestations, and poor renal and overall survival.