Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
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DOI：
10.1016/s0168-0102(02)00251-1
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发表时间：
2003-03-01
影响因子：
2.9
通讯作者：
Aou, S
中科院分区：
文献类型：
--
作者：
Kubo, K;Arai, O;Aou, S
环境内分泌干扰物（EEDs）可能影响性分化，这是内分泌学关注的问题。双酚A（BPA）是一种EEDs，从聚碳酸酯塑料中释放出来，并已在人类脐带中检测到。在这项研究中，我们研究了BPA对大鼠后代的旷场行为的性分化和大脑中的性二型核的影响，这些大鼠在胎儿和哺乳期暴露于BPA，剂量低于人类每日耐受摄入量（TDI）水平。在对照组中，女性更活跃在开放领域，并有一个更大的蓝斑（LC）体积比男性。BPA消除和逆转的开放领域的行为和LC体积的性别差异，分别，而不影响生殖系统。我们还比较了雌激素化合物，己烯雌酚（DES）和白藜芦醇（RVT）的影响，双酚A，因为它们的结构相似。DES影响旷场行为、LC体积和生殖系统，而RVT影响LC体积和生殖系统。这些结果表明，大脑是高度敏感的BPA在低于TDI的剂量和BPA对性分化的干扰作用可能不同于RVT和DES。(C)2003年爱思唯尔科学爱尔兰有限公司和日本神经科学学会。All rights reserved.
There is an endocrinological concern that environmental endocrine disrupters (EEDs) may influence sexual differentiation. Bisphenol A (BPA), one of EEDs, is released from polycarbonate plastics, and has been detected in the human umbilical cord. In this study, we examined the effect of BPA on the sexual differentiation of open-field behavior and the sexually dimorphic nuclei in the brain in the offspring of rats exposed to BPA during the fetal and suckling periods at a dosage below the human tolerable daily intake (TDI) level. In the control group, females were more active in the open field and had a larger locus coeruleus (LC) volume than males. BPA abolished and inverted the sex differences of the open-field behavior and the LC volume, respectively, without affecting the reproductive system. We also compared the effects of estrogenic compounds, diethylstilbestrol (DES) and resveratrol (RVT), to that of BPA because of their structural similarities. DES affected the open-field behavior, LC volume and reproductive system, while RVT affected the LC volume and the reproductive system. These results suggest that the brain is highly sensitive to BPA at a dosage below TDI and that the disrupting effects of BPA on sexual differentiation may vary from those of RVT and DES. (C) 2003 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.