Continuation drug therapy for major depressive episodes: how long should it be maintained?
Continuation drug therapy for major depressive episodes: how long should it be maintained?
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重度抑郁发作的持续药物治疗：应该维持多长时间？
DOI：
10.1176/ajp.143.1.18
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Kupfer,DJ
中科院分区：
文献类型：
--
作者：
Prien,RF;Kupfer,DJ
对于从业者来说，一个主要问题是缺乏令人满意的指南来说明抑郁发作的持续药物治疗必须维持多长时间以确保发作结束。这通常会导致过早停药并随后复发或不必要地延长治疗时间。美国国家心理健康研究所的一个合作项目的结果提供了第一个基于研究的关于持续治疗时间的指南。研究结果表明，只有在患者 16 至 20 周内没有出现明显症状后，停止此类治疗才是安全的，并且在做出此决定时，关注轻度和重度症状至关重要。
A major problem for the practitioner is the lack of satisfactory guidelines as to how long continuation drug treatment of depressive episodes must be maintained to ensure that the episode is over. This often leads to either premature withdrawal of the drug and subsequent relapse or unnecessarily prolonged treatment. Results from a collaborative project of the National Institute of Mental Health provide the first study-derived guidelines on the length of continuation therapy. Findings indicate that withdrawal of such therapy is safe only after the patient has been free of significant symptoms for 16 to 20 weeks and that focusing on mild as well as severe symptoms is critical in this decision.