BODY-WEIGHT AND WEIGHT-GAIN RELATED TO PULMONARY-FUNCTION DECLINE IN ADULTS - A 6 YEAR FOLLOW-UP-STUDY
BODY-WEIGHT AND WEIGHT-GAIN RELATED TO PULMONARY-FUNCTION DECLINE IN ADULTS - A 6 YEAR FOLLOW-UP-STUDY
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DOI：
10.1136/thx.48.4.375
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发表时间：
1993-04-01
期刊：
影响因子：
10
通讯作者：
DOSMAN, JA
中科院分区：
文献类型：
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作者：
CHEN, Y;HORNE, SL;DOSMAN, JA
背景-肥胖会增加心血管疾病、高血压、糖尿病、消化系统疾病和某些癌症的风险。一些研究表明，超重或体重增加与肺功能障碍有关，但这个问题需要进一步澄清。方法-该分析基于加拿大萨斯喀彻温省洪堡镇进行的洪堡队列研究的数据。1977年的基线调查包括1202名成年人，占25-59岁所有居民的94%。其中709人(59%)在一九八三年获得跟进。测量肺功能(用力肺活量(FVC)、一秒钟用力呼气容积(FEV1)和最大呼气中段流速(MMFR))和体重。体重增加是通过从随访时的体重减去基线体重来确定的。用残差分析检验基线体重指数(BMI)、体重增加和肺功能下降之间的关系。结果：基线BMI和体重增加都与随访时的肺功能显著相关。然而，在研究期间体重增加的影响更为突出。结果显示，平均残余FVC和FEV1在获得
Background-Obesity increases the risk of cardiovascular disease, hypertension, diabetes, digestive diseases, and some cancers. Several studies have shown that excess weight or weight gain is related to pulmonary dysfunction, but this issue needs to be further clarified.Methods-The analysis was based on data of the Humboldt cohort study which was conducted in the town of Humboldt, Saskatchewan, Canada. The baseline survey in 1977 included 1202 adults, comprising 94% of all residents aged 25-59 years. Of these, 709 (59%) were followed up in 1983. Pulmonary function (forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximal mid expiratory flow rate (MMFR)) and weight were measured in both, surveys. Weight gain was determined by subtracting weight at baseline from weight at follow up. A residual analysis was used to examine the relationship between body mass index (BMI) at baseline, weight gain, and pulmonary function decline.Results-Both BMI at baseline and weight gain were significantly related to pulmonary function at follow up. The effect of weight gain during the study period, however, was more prominent. The results showed that both mean residual FVC and FEV1 were highest in the group that gained