5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex
5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex
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DOI：
10.1016/s0893-133x(98)00046-3
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发表时间：
1999-01-01
影响因子：
7.6
通讯作者：
Deutch, AY
中科院分区：
文献类型：
--
作者：
Abi-Saab, WM;Bubser, M;Deutch, AY
单胺，包括多巴胺和5-羟色胺，与前额叶皮层中间神经元形成突触。多巴胺已被证明激活这些GABA能中间神经元，但没有直接数据表明5-羟色胺对前额叶皮层中GABA释放的影响。因此，我们研究了5-HT 2a/c激动剂1-（2，5-二甲氧基-4-碘苯基-2-氨基丙烷（DOI）对MT前额叶皮层细胞外GABA水平的影响。DOI剂量依赖性地增加皮质细胞外GABA水平。此外，系统DOI管理导致Fos蛋白在谷氨酸脱羧酶（67）免疫反应性的前额叶皮层的中间神经元的表达。这些数据表明，5-羟色胺，通过5-HT 2受体，急性激活GABA能中间神经元在前额皮质。这些数据进一步表明，可能有会聚调节的中间神经元的多巴胺和5-羟色胺在前额叶皮层。[Neuropsychopharmacology 20：92-96，1999]（C）1998年美国神经精神药理学学会。出版社：Elsevier Science Inc.
Monoamines, including both dopamine and serotonin, synapse onto prefrontal cortical interneurons. Dopamine has been shown to activate these GABAergic interneurons, but there are no direct data on the effects of serotonin on GABA release in the prefrontal cortex. We, therefore, examined the effects of the 5-HT2a/c agonist 1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI) on extracellular GABA levels in the prefrontal cortex of the mt. Local infusions of DOI dose-dependently increased cortical extracellular GABA levels. In addition, systemic DOI administration resulted in Fos protein expression in glutamic acid decarboxylase(67)-immunoreactive interneurons of the prefrontal cortex. These data indicate that serotonin, operating through a 5-HT2 receptor, acutely activates GABAergic interneurons in the prefrontal cortex. These data further suggest that there may be convergent regulation of interneurons by dopamine and serotonin in the prefrontal cortex. [Neuropsychopharmacology 20:92-96, 1999] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.