Hepatic Fat Content Is Associated with Fasting-Induced Fibroblast Growth Factor 21 Secretion in Mice Fed Soy Proteins
Hepatic Fat Content Is Associated with Fasting-Induced Fibroblast Growth Factor 21 Secretion in Mice Fed Soy Proteins
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DOI：
10.3177/jnsv.65.515
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发表时间：
2019-01-01
影响因子：
1.6
通讯作者：
Ishihara, Kengo
中科院分区：
文献类型：
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作者：
Taniguchi, Hirokazu;Akiyama, Nao;Ishihara, Kengo
先前的研究表明，脂肪肝患者的循环成纤维细胞生长因子21（FGF 21）水平升高，而肥胖患者的空腹诱导的FGF 21分泌较低。据报道，大豆蛋白可防止肝脏脂肪积聚并诱导FGF 21分泌。本研究旨在评估循环FGF 21水平对喂食富含大豆蛋白饮食的小鼠的喂食和禁食的反应。为此，将C57 BL/6 J小鼠分为对照组、高脂肪高蔗糖（HFHS）-酪蛋白组、HFHS-大豆蛋白组和HFHS-β-伴大豆球蛋白组。血浆样品收集后10和11周无论是在黑暗时期与喂养条件下或光周期禁食条件下使用交叉设计。经过12周的喂养，HFHS-大豆蛋白和HFHS-β-伴大豆球蛋白喂养组的HFHS诱导的肝脏脂肪堆积与HFHS-酪蛋白喂养组相比显著减少（p
Previous studies suggest that circulating fibroblast growth factor 21 (FGF21) levels are elevated in patients with fatty liver, while fasting-induced secretion of FGF21 is lower in obese patients. It has been reported that soy protein prevents hepatic fat accumulation and induces FGF21 secretion. The present study was designed to evaluate the response of circulating FGF21 levels to feeding and fasting in mice fed soy protein-rich diets. For this, C57BL/6J mice were distributed into control, high-fat high-sucrose (HFHS)-casein protein, HFHS-soy protein, and HFHS-beta-conglycinin diet groups. Plasma samples were collected after 10 and 11 wk either in dark periods with feeding conditions or light periods under fasting conditions using a crossover design. After a 12-wk period of feeding, HFHS-induced hepatic fat accumulation was significantly reduced in the groups fed HFHS-soy protein and HFHS-beta-conglycinin as compared to that in the HFHS-casein-fed group (p