Impairment of long-term memory and sparing of short-term memory in monkeys with medial temporal lobe lesions: a response to Ringo.
Impairment of long-term memory and sparing of short-term memory in monkeys with medial temporal lobe lesions: a response to Ringo.
复制标题
内侧颞叶损伤的猴子的长期记忆受损和短期记忆保留：对林戈的反应。
DOI：
10.1016/s0166-4328(05)80319-5
复制
发表时间：
1992
影响因子：
2.7
通讯作者：
Squire,LR
中科院分区：
文献类型：
--
作者：
Alvarez-Royo,P;Zola-Morgan,S;Squire,LR
在过去的十年里，在猴子身上开发了一种人类健忘症的动物模型。使用这种模型的研究已经确定了内侧颞叶中对形成长期记忆至关重要的结构（即海马体和内嗅、嗅周和海马旁皮质）。最近，这些研究的一个重要方面提出了质疑林戈（Behav。Brain Res.，42（1991）123-134）。他认为，在这些研究中广泛使用的延迟非匹配样本任务的数据以一种潜在的误导方式进行了分析。他重新分析了来自几个实验室的数据，将正确率数据转换为基于信号检测理论的可分辨性（d '）测量。在有病变的猴子中，表现似乎在短期和长期保留延迟时同等受损。他的结论是，这些数据不支持内侧颞叶损伤会损害长期记忆，但不会损害短期记忆的观点。然而，他分析的大多数研究都不是为了解决短期记忆和长期记忆之间的区别。我们在这里表明，在研究中，旨在比较短期和长期的记忆直接，内侧颞叶病变损害长期记忆，而留下短期记忆完好无损。无论数据是使用百分比正确测量、d'测量还是反正弦变换进行分析，都可以获得该结果。
During the last decade, an animal model of human amnesia was developed in the monkey. Studies using this model have identified structures in the medial temporal lobe that are essential for forming long-term memory (i.e. the hippocampus and the entorhinal, perirhinal and parahippocampal cortices). Recently, an important aspect of these studies was questioned by Ringo (Behav. Brain Res., 42 (1991) 123–134). He suggested that the data from the delayed non-matching-to-sample task, which has been extensively used in these studies, have been analyzed in a potentially misleading way. He reanalyzed the data from several laboratories by transforming percent correct data to a discriminability (d') measure based on signal detection theory. In monkeys with lesions, performance appeared to be equivalently impaired at short and long retention delays. He concluded that the data do not support the idea that medial temporal lobe damage produces an impairment in long-term memory, but not short-term memory. However, most of the studies he analyzed were not designed to address the distinction between short-term and long-term memory. We show here that, in studies designed to compare short-term and long-term memory directly, medial temporal lobe lesions impair long-term memory while leaving short-term memory intact. This result is obtained whether the data are analyzed using a percent correct measure, the d' measure, or an arcsine transform.