CONTROL OF EXTRACELLULAR POTASSIUM LEVELS BY RETINAL GLIAL-CELL K+ SIPHONING
CONTROL OF EXTRACELLULAR POTASSIUM LEVELS BY RETINAL GLIAL-CELL K+ SIPHONING
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DOI：
10.1126/science.6474173
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
ODETTE, LL
中科院分区：
文献类型：
--
作者：
NEWMAN, EA;FRAMBACH, DA;ODETTE, LL
用离子选择性微电极测定了K+从蝾螈Mueller细胞中的流出。当一个孤立的细胞的远端暴露于高浓度的细胞外K+，流出发生主要从endfoot，细胞过程中先前显示包含大部分的K+电导的细胞膜。视网膜中K+动力学的计算机模拟表明，通过Mueller细胞尾足过程的分流离子在清除视网膜中细胞外K+的局部增加方面比通过细胞外空间的扩散更有效。
Efflux of K+ from dissociated salamander Mueller cells was measured with ion-selective microelectrodes. When the distal end of an isolated cell was exposed to high concentrations of extracellular K+, efflux occurred primarily from the endfoot, a cell process previously shown to contain most of the K+ conductance of the cell membrane. Computer simulations of K+ dynamics in the retina indicate that shunting ions through the Mueller cell endfoot process is more effective in clearing local increases in extracellular K+ from the retina than is diffusion through extracellular space.