Neuregulins and cancer
Neuregulins and cancer
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DOI：
10.1158/1078-0432.ccr-07-5133
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发表时间：
2008-06-01
影响因子：
11.5
通讯作者：
Pandiella, Atanasio
中科院分区：
文献类型：
--
作者：
Montero, Juan Carlos;Rodriguez-Barrueco, Ruth;Pandiella, Atanasio
神经调节蛋白是表皮生长因子配体家族中最大的多肽因子亚类。这些分子通过与HER/ErbB受体酪氨酸激酶结合而合成为膜结合的生物活性生长因子。临床前数据表明，神经调节蛋白的表达和功能增加可能引发癌症。此外，神经调节蛋白表达已在几种肿瘤中被检测到，它们的存在可能与靶向HER受体（如曲妥珠单抗）的治疗反应有关。此外，神经调节蛋白也与抗her疗法的耐药性有关。因此，靶向神经调节蛋白可能有助于肿瘤疾病，其中这些多肽因子有助于肿瘤的产生和/或维持。
The neuregulins represent the largest subclass of polypeptide factors of the epidermal growth factor family of ligands. These molecules are synthesized as membrane-bound, biologically active growth factors that act by binding to the HER/ErbB receptor tyrosine kinases. Preclinical data have indicated that increased expression and function of neuregulins may provoke cancer. Furthermore, neuregulin expression has been detected in several neoplasias, and their presence may correlate with response to treatments that target the HER receptors such as trastuzumab. In addition, the neuregulins have also been implicated in resistance to anti-HER therapies. Therefore, targeting of the neuregulins may be helpful in neoplastic diseases in which these polypeptide factors contribute to tumor generation and/or maintenance.