Protease-mediated ectodomain shedding
Protease-mediated ectodomain shedding
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DOI：
10.1136/thoraxjnl-2013-204403
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发表时间：
2014-07-01
期刊：
影响因子：
10
通讯作者：
Clark, Peter
中科院分区：
文献类型：
--
作者：
Clark, Peter
胞外域脱落是细胞表面蛋白的蛋白水解裂解，导致胞外域的丢失。这种机制在各种正常和病理过程中都很重要，包括生长因子信号传导、细胞粘附、炎症和细胞存活。肺部蛋白酶活性升高是肺气肿的关键病理机制，可以增强肺细胞的胞外域脱落。在这里，回顾了胞外域脱落的主要步骤和后果。
Ectodomain shedding is the proteolytic cleavage of cell surface proteins resulting in the loss of the extracellular domains. This mechanism is important in a variety of normal and pathological processes, including growth factor signalling, cell adhesion, inflammation and cell survival. Elevated protease activity in the lungs is a key pathological mechanism in emphysema which could enhance ectodomain shedding in lung cells. Here, the major steps and consequences of ectodomain shedding are reviewed.