Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.
Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits.
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DOI：
10.1016/bs.irn.2016.03.015
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发表时间：
2016
影响因子：
--
通讯作者：
Yan J
中科院分区：
文献类型：
--
作者：
Li Q;Yan J
大电导、Ca 2+和电压激活的K+（BK）通道在哺乳动物组织中广泛表达，并显示出不同的生物物理或药理学特征。这种多样性部分是由具有不同调节辅助亚基的通道调节所赋予的。迄今为止，已经鉴定了两种不同类型的BK通道辅助亚基：β亚基和γ亚基。在过去的二十年里，四个辅助β（β1-β4）亚基对BK通道的调节已经得到了很好的建立和深入的研究。然而，辅助γ亚基只是最近才被发现，这为BK通道的调节增加了一个新的维度，并提高了我们对BK通道在各种组织和细胞类型中的生理功能的理解。本章将回顾目前对辅助β和γ亚基调节BK通道的认识，特别是最新的发现。
The large-conductance, Ca2+- and voltage-activated K+ (BK) channel is ubiquitously expressed in mammalian tissues and displays diverse biophysical or pharmacological characteristics. This diversity is in part conferred by channel modulation with different regulatory auxiliary subunits. To date, two distinct classes of BK channel auxiliary subunits have been identified: β subunits and γ subunits. Modulation of BK channels by the four auxiliary β (β1–β4) subunits has been well established and intensively investigated over the past two decades. The auxiliary γ subunits, however, were identified only very recently, which adds a new dimension to BK channel regulation and improves our understanding of the physiological functions of BK channels in various tissues and cell types. This chapter will review the current understanding of BK channel modulation by auxiliary β and γ subunits, especially the latest findings.
DOI：
10.1085/jgp.200810079
发表时间：
2009-03
期刊：
The Journal of general physiology
影响因子：
--
作者：
Zhang Z;Zeng XH;Xia XM;Lingle CJ
通讯作者：
Lingle CJ