Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers.
Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers.
复制标题
使用 H-ras 1 和 INS DNA 标记对爱尔兰家庭躁狂抑郁症进行连锁分析。
DOI：
10.1136/jmg.25.9.634
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发表时间：
1988
影响因子：
4
通讯作者：
Peter Humphries
中科院分区：
文献类型：
--
作者：
Michael Gill;Patrick McKEoNt;Peter Humphries
躁狂抑郁症（双相情感障碍）是主要的精神疾病之一。它与单相重性抑郁症的区别在于躁狂发作的发生，躁狂发作的症状表现为情绪高涨和膨胀、坐立不安、易怒、言语压力、去抑制、精力增加和宏伟的想法或妄想的可变组合。在研究的大多数人群中，它的终生风险略低于1%。双胞胎和收养研究表明，遗传因素很大。Egeland等人已经证明了一个北美家系中的躁狂抑郁症表型与11号染色体短臂顶端的两个多态性DNA标记之间的连锁。其他的研究未能显示在冰岛和其他北美血统中的这种联系。我们已经排除了这些DNA标记与躁狂抑郁表型之间的紧密联系，假设该疾病在爱尔兰大谱系中作为常染色体显性特征分离。一个单一的，单方面的躁狂抑郁症的来源是可能的，但不能被证明。这些诊断是基于斯皮策等人的研究诊断标准，4使用访谈、病例记录回顾和精神分裂症和情感障碍终身版（SADS-L）的组合进行编辑。所有病例均为双相情感障碍，
Manic depression (bipolar affective disorder) is one of the major psychiatric illnesses. It is distinguished from unipolar major depression by the occurrence of manic episodes, symptoms of which show a variable combination of heightened and expansive mood, restlessness, irritability, pressure of speech, disinhibition, increased energy, and grandiose ideas or delusions. It has a lifetime risk of slightly less than 1% in most populations studied. A large genetic component has been shown using twin and adoption studies. Egeland et all have shown linkage between the manic depressive phenotype in one North American pedigree and two polymorphic DNA markers on the tip of the short arm of chromosome 11. Other studies2 ' have failed to show this linkage in Icelandic and other North American pedigrees. We have ruled out tight linkage between these DNA markers and the manic depressive phenotype, assuming that the disorder is segregating as an autosomal dominant trait in a large Irish pedigree. A single, unilateral source of the manic depression is likely but cannot be proven. The diagnoses were based on the Research Diagnostic Criteria of Spitzer et al,4 compiled using a combination of interviews, a review of the case notes, and the Schizophrenia and Affective Disorders Schedule-Lifetime Version (SADS-L). All cases were of bipolar affective disorder, apart from