Regeneration and repair of the exocrine pancreas.
Regeneration and repair of the exocrine pancreas.
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DOI：
10.1146/annurev-physiol-021014-071727
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发表时间：
2015
影响因子：
18.2
通讯作者：
Keefe MD
中科院分区：
文献类型：
--
作者：
Murtaugh LC;Keefe MD
胰腺炎是由外分泌胰腺的炎性损伤引起的，人类和动物模型似乎都通过产生消化酶的腺泡细胞的再生而恢复。这一再生过程涉及炎症、化生和再分化的过渡阶段，由腺泡细胞、白细胞和驻留成纤维细胞之间的细胞 - 细胞相互作用驱动。NFκB信号通路是胰腺炎症和化生的关键决定因素，而一些发育信号和转录因子致力于在损伤后促进腺泡再分化。这些促炎和促分化通路之间的失衡导致慢性胰腺炎，其特征是持续的炎症、纤维化和腺泡去分化。腺泡细胞分化的丧失也驱动胰腺癌的发生，提供了胰腺炎和癌症风险之间的机制联系。揭示外分泌再生的分子基础可能会为治疗和预防这两种致命疾病确定新的治疗靶点。
Pancreatitis is caused by inflammatory injury to the exocrine pancreas, from which both humans and animal models appear to recover via regeneration of digestive enzyme-producing acinar cells. This regenerative process involves transient phases of inflammation, metaplasia and redifferentiation, driven by cell-cell interactions between acinar cells, leukocytes and resident fibroblasts. The NFκB signaling pathway is a critical determinant of pancreatic inflammation and metaplasia, whereas a number of developmental signals and transcription factors are devoted to promoting acinar redifferentiation after injury. Imbalances between these pro-inflammatory and pro-differentiation pathways contribute to chronic pancreatitis, characterized by persistent inflammation, fibrosis and acinar dedifferentiation. Loss of acinar cell differentiation also drives pancreatic cancer initiation, providing a mechanistic link between pancreatitis and cancer risk. Unraveling the molecular bases of exocrine regeneration may identify new therapeutic targets for treatment and prevention of both of these deadly diseases.
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影响因子：
29.4
作者：
Fukuda A;Morris JP 4th;Hebrok M
通讯作者：
Hebrok M
影响因子：
29.4
作者：
Demols, A;Le Moine, O;Devière, J
通讯作者：
Devière, J
影响因子：
29.4
作者：
Frossard, JL;Rubbia-Brandt, L;Chanson, M
通讯作者：
Chanson, M
树突状细胞促进急性胰腺炎小鼠的胰腺生存力。
影响因子：
29.4
作者：
Bedrosian AS;Nguyen AH;Hackman M;Connolly MK;Malhotra A;Ibrahim J;Cieza-Rubio NE;Henning JR;Barilla R;Rehman A;Pachter HL;Medina-Zea MV;Cohen SM;Frey AB;Acehan D;Miller G
通讯作者：
Miller G
DOI：
10.4161/cc.8.12.8744
发表时间：
2009-06-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
De La O JP;Murtaugh LC
通讯作者：
Murtaugh LC