Oxidative stress and antioxidant status in prostate cancer patients: Relation to Gleason score, treatment and bone metastasis
Oxidative stress and antioxidant status in prostate cancer patients: Relation to Gleason score, treatment and bone metastasis
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DOI：
10.1016/j.biopha.2011.06.003
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发表时间：
2011-10-01
影响因子：
7.5
通讯作者：
Morsch, Vera M.
中科院分区：
文献类型：
--
作者：
Battisti, Vanessa;Maders, Liesi D. K.;Morsch, Vera M.
在过去的十年中，流行病学、实验和临床研究表明，氧化应激与前列腺癌的发生和发展有关。在本研究中，我们评估了前列腺癌患者的氧化状态和抗氧化防御，考虑了治疗、Gleason评分和骨转移。为此，我们测量了血浆硫代巴比妥酸反应物质(TBARS)浓度、血清蛋白羧化、全血过氧化氢酶(CAT)和超氧化物歧化酶(SOD)活性，以及血浆和红细胞硫醇水平以及血清维生素C和维生素E浓度。本研究对55例前列腺癌患者和55例健康男性进行了研究。PCa患者的血清总胆红素受体水平和血清蛋白羧化水平高于对照组，这些患者体内的抗氧化剂水平也发生了变化。与正常对照组比较，PCa组CAT活性降低，SOD活性升高。与对照组相比，前列腺癌患者的非蛋白硫醇水平升高，而血清维生素C和维生素E含量降低。此外，根据转移、治疗和Gleason评分对PCA患者进行的不同参数分析显示，氧化应激生物标记物和抗氧化防御发生了变化。这些发现可能表明氧化/抗氧化状态失衡，支持氧化应激在前列腺癌中起作用的观点，此外，骨转移、治疗和Gleason评分似乎改变了氧化状态。(C)2011年爱思唯尔·马森公司。版权所有。
Over the last decade, epidemiological, experimental and clinical studies have implicated oxidative stress in the development and progression of prostate cancer. In the present study, we evaluated the oxidative status and antioxidant defense in patients with prostate cancer (PCa) taking into consideration: treatment, Gleason score and bone metastasis. For this, we measured concentrations of plasmatic thiobarbituric acid reactive substances (TBARS), serum protein carbonylation, whole blood catalase (CAT) and superoxide dismutase (SOD) activities, as well as the plasma and erythrocyte thiol levels and serum vitamin C and E concentration. This study was performed on 55 patients with PCa and 55 healthy men. TBARS levels and serum protein carbonylation were higher in PCa patients than in controls and altered levels of antioxidants were found in these patients. CAT activity was decreased and SOD activity was higher in PCa patients when compared with controls. Non-protein thiol levels were increased, however, serum vitamin C and vitamin E content were reduced in PCa patients when compared with controls. In addition, different parameters analyzed in PCa patients based on metastasis, treatment and Gleason score showed changes in oxidative stress biomarkers and antioxidant defenses. These findings may indicate an imbalance in the oxidant/antioxidant status, supporting the idea that oxidative stress plays a role in PCa, moreover, the oxidative profile appear to be modified by bone metastasis, treatment and Gleason score. (C) 2011 Elsevier Masson SAS. All rights reserved.