Controlled non-heart-beating donor liver transplantation - A successful single center experience, with topic update
Controlled non-heart-beating donor liver transplantation - A successful single center experience, with topic update
复制标题
DOI：
10.1097/00007890-200010270-00006
复制
发表时间：
2000-10-27
期刊：
影响因子：
6.2
通讯作者：
Manzarbeitia, CY
中科院分区：
文献类型：
--
作者：
Reich, DJ;Munoz, SJ;Manzarbeitia, CY
背景。可移植器官的严重短缺使得必须利用非常规供体。我们描述了受控无心跳供体（NHBD）肝移植的成功经验。方法。受控的 NHBD 患有灾难性头部损伤，预后无有意义的恢复，决定撤回生命支持，并随后同意捐赠。在手术室停止机械通气后，由非移植护理人员确定死亡，并快速主动脉插管，肝脏和肾脏恢复。结果。从 1996 年 8 月到 1999 年 6 月，受控的 NHBD 贡献了同种异体肝移植的 5% (8/164)（1998 年为 9%），16 个 NHBD 提供了 8 个肝脏和 24 个肾脏。肝脏捐献者（n=8）年龄为11-66岁；一半>50岁。死前丙氨酸转氨酶为 25-157 Un。停止通气后 3-27 分钟发生逮捕。切开后3-5分钟开始灌注，
Background. The critical shortage of transplantable organs necessitates utilization of unconventional donors. We describe a successful experience of controlled non-heart-beating donor (NHBD) liver transplantation.Methods. Controlled NHBDs had catastrophic head injury, prognosis for no meaningful recovery, decision to withdraw life support, and subsequent consent for donation. After stopping mechanical ventilation in the operating room, death determination by a nontransplant caregiver, and rapid aortic cannulation, liver and kidneys were recovered.Results. Controlled NHBDs contributed 5% of hepatic allografts (8/164) from August 1996 through June 1999 (9% in 1998), Sixteen NHBDs afforded 8 livers and 24 kidneys. Liver donors (n=8) were 11-66 years old; half were >50 years old. Premortem alanine aminotransferase was 25-157 Un. Arrest occurred 3-27 min after stopping ventilation. Perfusion started 3-5 min after incision, and