Total cerebral blood flow and mortality in old age A 12-year follow-up study
Total cerebral blood flow and mortality in old age A 12-year follow-up study
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DOI：
10.1212/01.wnl.0000436618.48402.da
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发表时间：
2013-11-26
期刊：
影响因子：
9.9
通讯作者：
de Craen, Anton J. M.
中科院分区：
文献类型：
--
作者：
Sabayan, Behnam;van der Grond, Jeroen;de Craen, Anton J. M.
目的：研究全脑血流量（CBF）与全因，非心血管，心血管死亡率在老年人的心血管疾病的风险，方法：我们纳入了411例受试者的平均年龄为74.5岁的前瞻性研究普伐他汀在老年人的风险MRI子研究。在基线时测量总CBF，并在平均11.8年的随访期内记录死亡发生率。对于每个参与者，总CBF被标准化为脑实质体积。考克斯回归模型被用来估计与CBF.Results相关的全因、非心血管和心血管死亡率的风险：总CBF的低、中和高三分之一参与者的死亡率分别为52.1、41.5和28.7/1000人年。与CBF高三分之一的参与者相比，低三分之一的参与者有1.88倍（95%置信区间[CI]：1.30-2.72）全因死亡风险增加1.66倍（95% CI：1.06-2.59）非心血管死亡风险增加，心血管死亡风险增加2.50倍（95% CI：1.28-4.91）。同样，与CBF高三分之一的参与者相比，中三分之一的参与者的全因死亡风险高1.44倍（95%CI：0.98-2.11），非心血管死亡风险高1.29倍（95%CI：0.82-2.04），心血管死亡风险高1.86倍（95%CI：0.93-3.74）。这些协会是独立的流行的血管状态和riskfactors.Conclusions：低总CBF与高风险的全因，非心血管，心血管死亡率在老年人独立的临床心血管状态。
Objective: To examine the association of total cerebral blood flow (CBF) with all-cause, noncardiovascular, and cardiovascular mortality in older subjects at risk of cardiovascular disease.Methods: We included 411 subjects with a mean age of 74.5 years from the MRI substudy of the Prospective Study of Pravastatin in the Elderly at Risk. Total CBF was measured at baseline, and occurrence of death was recorded in an average follow-up period of 11.8 years. For each participant, total CBF was standardized for brain parenchymal volume. Cox regression models were used to estimate risk of all-cause, noncardiovascular, and cardiovascular mortality in relation to CBF.Results: Mortality rates among participants in low, middle, and high thirds of total CBF were 52.1, 41.5, and 28.7 per 1,000 person-years, respectively. Compared with participants in the high third of CBF, participants in the low third had 1.88-fold (95% confidence interval [CI]: 1.30-2.72) higher risk of all-cause mortality, 1.66-fold (95% CI: 1.06-2.59) higher risk of noncardiovascular mortality, and 2.50-fold (95% CI: 1.28-4.91) higher risk of cardiovascular mortality. Likewise, compared with participants in the high third of CBF, participants in the middle third had 1.44-fold (95% CI: 0.98-2.11) higher risk of all-cause mortality, 1.29-fold (95% CI: 0.82-2.04) higher risk of noncardiovascular mortality, and 1.86-fold (95% CI: 0.93-3.74) higher risk of cardiovascular mortality. These associations were independent of prevalent vascular status and risk factors.Conclusions: Low total CBF is linked with higher risk of all-cause, noncardiovascular, and cardiovascular mortality in older people independent of clinical cardiovascular status.