Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome
Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome
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DOI：
10.1086/374666
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发表时间：
2003-05-01
影响因子：
11.8
通讯作者：
Bruce, IN
中科院分区：
文献类型：
--
作者：
Kerr, JR;Cunniffe, VS;Bruce, IN
3例急性细小病毒B19感染后的慢性疲劳综合征（CFS）患者接受5天静脉注射免疫球蛋白（IVIG； 400 mg/kg /天）治疗，这是对细小病毒B19感染的唯一特异性治疗。我们检测了IVIG治疗对细小病毒B19引起的CFS个体细胞因子和趋化因子产生的影响。IVIG治疗导致所有患者细小病毒B19病毒血症的清除，症状的缓解，身体和功能的改善，以及细胞因子失调的解决。
Three cases of chronic fatigue syndrome (CFS) that followed acute parvovirus B19 infection were treated with a 5-day course of intravenous immunoglobulin ( IVIG; 400 mg/kg per day), the only specific treatment for parvovirus B19 infection. We examined the influence of IVIG treatment on the production of cytokines and chemokines in individuals with CFS due to parvovirus B19. IVIG therapy led to clearance of parvovirus B19 viremia, resolution of symptoms, and improvement in physical and functional ability in all patients, as well as resolution of cytokine dysregulation.