Baseline Characteristics of Participants in the Randomized National Lung Screening Trial
Baseline Characteristics of Participants in the Randomized National Lung Screening Trial
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DOI：
10.1093/jnci/djq434
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发表时间：
2010-12-01
影响因子：
10.3
通讯作者：
Pinsky, Paul F.
中科院分区：
文献类型：
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作者：
Aberle, Denise R.;Adams, Amanda M.;Pinsky, Paul F.
国家肺筛查试验（NLST）是一项在美国33个地点进行的随机研究，比较了接受低剂量螺旋计算机断层扫描和胸片筛查的肺癌死亡率。在本文中，我们介绍了研究人群的特征。方法符合条件的参与者年龄在55-74岁之间，吸烟史至少30包年的吸烟者或曾经吸烟者。随机分组按地点、性别和年龄分层。为了评估研究人群的代表性，从美国人口普查局当前人口调查的烟草使用补充中获得了符合NLST年龄和吸烟史纳入标准的普通人群的人口统计学特征。结果NLST共纳入53 456人，其中26 733人随机分配到胸片筛查组，26 723人随机分配到计算机断层扫描组。参与者的特征如下：31 533人（59%）是男性，39 234人（73%）是65岁以下的年轻人，25 779人（48%）是目前的吸烟者，16 839人（32%）拥有大学或更高的学位。香烟暴露的中位数为48包年。在符合NLST年龄和吸烟史标准的烟草使用补充调查对象中，59%为男性，65%小于65岁，57%为当前吸烟者。这群人吸烟的中位数为47包年，14%的人拥有大学或更高学历。结论：NLST队列的性别分布和包年史与符合NLST主要资格标准的美国普通人群相似；然而，NLST的参与者更年轻，受教育程度更高，吸烟的可能性更小。
Background The National Lung Screening Trial (NLST), a randomized study conducted at 33 US sites, is comparing lung cancer mortality among persons screened with reduced dose helical computerized tomography and among persons screened with chest radiograph. In this article, we present characteristics of the study population.Methods Eligible participants were aged 55-74 years and were current or former smokers with a cigarette smoking history of at least 30 pack-years. Randomization was stratified by site, sex, and age. To assess representativeness of the study population, demographic characteristics of individuals from the general population who met NLST age and smoking history inclusion criteria were obtained from the Tobacco Use Supplement of the US Census Bureau Current Population Surveys.Results The NLST enrolled 53 456 persons, with 26 733 randomly assigned to chest radiograph screening and 26 723 to computerized tomography screening. Characteristics of the participants were as follows: 31 533 (59%) were men, 39 234 (73%) were younger than 65 years, 25 779 (48%) were current smokers, and 16 839 (32%) had a college or higher degree. Median cigarette exposure was 48 pack-years. Among Tobacco Use Supplement respondents who met NLST age and smoking history criteria, 59% were men, 65% were younger than 65 years, and 57% were current smokers. Median cigarette exposure among this group was 47 pack-years, and 14% had a college degree or higher.Conclusion The NLST cohort has a distribution of sex and pack-year history that is similar to the component of the general US population that meets the major NLST eligibility criteria; however, NLST participants are younger, better educated, and less likely to be current smokers.