Plasma hormonal profiles and dendritic spine density and morphology in the hippocampal CA1 stratum radiatum, evidenced by light microscopy, of virgin and postpartum female rats
Plasma hormonal profiles and dendritic spine density and morphology in the hippocampal CA1 stratum radiatum, evidenced by light microscopy, of virgin and postpartum female rats
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DOI：
10.1016/j.neulet.2008.04.063
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发表时间：
2008-06-27
影响因子：
2.5
通讯作者：
Rasia-Filho, Alberto A.
中科院分区：
文献类型：
--
作者：
Brusco, Janaina;Wittmann, Raul;Rasia-Filho, Alberto A.
成功的生殖需要血浆促卵泡激素（FSH）、促黄体生成素（LH）、催乳素（PRL）、催产素（OT）、雌激素（E-2）和孕酮（P-4）的变化与母性行为的表现同时发生。卵巢激素和环境刺激可影响大鼠海马树突棘。在此，以Wistar大鼠为研究对象，描述了：（a）与发情周期参考值相比，雌性大鼠在产后（PP）4、8、12、16、20和24天的激素谱的顺序和伴随变化;（B）在整个发情周期和多胎年龄的未交配雌性中CA 1（CA 1-SR）高尔基体浸渍的神经元的放射层中的树突棘密度，匹配的;（c）在动情间期，处女和产后雌鼠的CAI-SR中不同类型棘的比例。血浆促性腺激素和卵巢激素水平保持低沿着PP，而LH增加和PRL下降接近哺乳期结束。动情期处女雌鼠树突棘密度最低，与动情间期、动情前期和产后动情间期雌鼠相比，差异显著（p < 0.03）。组间其他比较无统计学意义（p > 0.4）。不同脊柱类型所占比例在初产和产后妇女中无差异（p > 0.2）。结果表明，中层CA 1-SR棘在整个发情周期的Wistar女性（不太可比的Sprague-Dawley数据或激素替代治疗卵巢切除术后）进行快速修改，但在这方面没有发现持久的影响，母亲对树突棘密度和形态。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
Successful reproduction requires that changes in plasma follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), oxytocin (OT), estrogen (E-2) and progesterone (P-4) occur together with the display of maternal behaviors. Ovarian steroids and environmental stimuli can affect the dendritic spines in the rat hippocampus. Here, studying Wistar rats, it is described: (a) the sequential and concomitant changes in the hormonal profile of females at postpartum days (PP) 4, 8, 12, 16, 20 and 24, comparing to estrous cycle referential values; (b) the dendritic spine density in the stratum radiatum of CA1 (CA1-SR) Golgi-impregnated neurons in virgin females across the estrous cycle and in multiparous age-matched ones; and (c) the proportion of different types of spines in the CAI-SR of virgin and postpartum females, both in diestrus. Plasma levels of gonadotrophins and ovarian hormones remained low along PP while LH increased and PRL decreased near the end of the lactating period. The lowest dendritic spine density was found in virgin females in estrus when compared to diestrus and proestrus phases or to postpartum females in diestrus (p < 0.03). Other comparisons among groups were not statistically significant (p > 0.4). There were no differences in the proportions of the different spine types in nulliparous and postpartum females (p > 0.2). Results suggest that medium layer CA1-SR spines undergo rapid modifications in Wistar females across the estrous cycle (not quite comparable to Sprague-Dawley data or to hormonal substitutive therapy following ovariectomy), but persistent effects of motherhood on dendritic spine density and morphology were not found in this area. (c) 2008 Elsevier Ireland Ltd. All rights reserved.