Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.
Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.
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发表时间：
2003
影响因子：
2.7
通讯作者：
Takaaki Hirai;K. Chida
中科院分区：
文献类型：
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作者：
Takaaki Hirai;K. Chida
蛋白激酶C的zeta同型（PKCzeta）是非典型PKC亚家族的成员，广泛参与细胞功能的调节。来自体外和体内系统的越来越多的证据表明，PKCzeta是由各种细胞外刺激诱导的关键细胞内信号通路的关键调节剂。PKCzeta的主要激活途径依赖于磷脂酰肌醇(PI)-3,4,5-三磷酸（PIP(3)），主要由PI-3激酶产生。3'- pi依赖性蛋白激酶1，与PIP(3)高亲和力结合，磷酸化并激活PKCzeta。许多研究表明PKCzeta参与有丝分裂原激活的蛋白激酶级联、转录因子NFkappaB激活、核糖体s6蛋白激酶信号传导和细胞极性。细胞中一个重要的分子事件是PKCzeta与其他信号分子以及支架蛋白结合，形成调节其通路的大复合物。对PKCzeta介导的细胞内信号传导控制机制的理解开始为PKCzeta在各种细胞中的作用提供重要的见解。
The zeta isotype of protein kinase C (PKCzeta) is a member of the atypical PKC subfamily and has been widely implicated in the regulation of cellular functions. Increasing evidence from studies using in vitro and in vivo systems points to PKCzeta as a key regulator of critical intracellular signaling pathways induced by various extracellular stimuli. The major activation pathway of PKCzeta depends on phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP(3)), which is mainly produced by PI-3 kinase. 3'-PI-dependent protein kinase 1, which binds with high affinity to PIP(3), phosphorylates and activates PKCzeta. Many studies demonstrated the involvement of PKCzeta in the mitogen-activated protein kinase cascade, transcriptional factor NFkappaB activation, ribosomal S6-protein kinase signaling, and cell polarity. An important molecular event in a cell is the association of PKCzeta with other signaling molecules, as well as scaffold proteins, to form large complexes that regulate their pathways. The understanding of the mechanisms underlying PKCzeta-mediated control of intracellular signaling is beginning to provide important insights into the roles of PKCzeta in various cells.