Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus.
Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus.
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DOI：
10.1002/0471142735.im1912s55
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发表时间：
2003-08-01
影响因子：
--
通讯作者：
Urban, Joseph Jr
中科院分区：
文献类型：
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作者：
Camberis, Mali;Le Gros, Graham;Urban, Joseph Jr
巴西尼波圆线虫和多回Heligmosomoides感染动物模型是研究免疫反应和保护性免疫基础生物学的有力工具。特别是，它们模拟了Th2型免疫反应的诱导和维持，并表现出CD4 T细胞依赖性IgE产生、嗜酸性粒细胞增多、肥大细胞增多和粘液产生的所有必要特征。本章描述了在现代实验室中使用和维护这些易于处理的寄生虫的简单、经济有效的技术。
Animal models of Nippostrongylus brasiliensis and Heligmosomoides polygyrus infection are powerful tools for the investigation of the basic biology of immune responses and protective immunity. In particular, they model the induction and maintenance of Th2 type immune responses and exhibit all the requisite hallmarks of CD4 T cell-dependent IgE production, eosinophilia, mastocytosis, and mucus production. This chapter describes simple, cost-effective techniques for using and maintaining these easy-to-work-with parasites in the context of a modern laboratory.