Hypoxia-regulated microRNAs in human cancer.
Hypoxia-regulated microRNAs in human cancer.
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DOI：
10.1038/aps.2012.195
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发表时间：
2013-03
影响因子：
8.2
通讯作者：
Xi, Yaguang
中科院分区：
文献类型：
--
作者：
Shen, Guomin;Li, Xiaobo;Jia, Yong-feng;Plazza, Gary A.;Xi, Yaguang
关键词：
缺氧通过允许癌细胞的发展和维持在肿瘤微环境中起着重要作用，但是肿瘤细胞适应缺氧条件的调节机制尚未得到很好的理解。MicroRNA被认为是一类新的控制基因表达的主调节因子，并负责许多正常和病理性细胞过程。研究表明，低氧诱导因子1（HIF 1）调节一组microRNA，而一些microRNA靶向HIF 1。microRNA和HIF 1之间的相互作用可以解释许多与肿瘤发生相关的生命事件，如血管生成、代谢、凋亡、细胞周期调控、增殖、转移和对抗癌治疗的抗性。本文综述了近年来关于低氧和microRNA在人类癌症中的作用的研究结果，并阐述了microRNA与肿瘤细胞中低氧相互作用的机制。这一结果将有助于我们进一步了解microRNA在肿瘤微环境调控中的作用，从而有助于开发新的抗肿瘤药物。
Hypoxia plays an important role in the tumor microenvironment by allowing the development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 (HIF1) regulates a panel of microRNAs, whereas some of microRNAs target HIF1. The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis, such as angiogenesis, metabolism, apoptosis, cell cycle regulation, proliferation, metastasis, and resistance to anticancer therapy. This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells. It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvironments and thus benefit the development of new anticancer drugs.
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影响因子：
3.7
作者：
Wang B;Zhang SG;Wang XF;Tan M;Xi Y
通讯作者：
Xi Y
DOI：
10.4161/cc.9.6.11006
发表时间：
2010-03-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Chan SY;Loscalzo J
通讯作者：
Loscalzo J
影响因子：
3.7
作者：
Favaro E;Ramachandran A;McCormick R;Gee H;Blancher C;Crosby M;Devlin C;Blick C;Buffa F;Li JL;Vojnovic B;Pires das Neves R;Glazer P;Iborra F;Ivan M;Ragoussis J;Harris AL
通讯作者：
Harris AL
影响因子：
11.2
作者：
Chen, Hsin-Yi;Lin, Yu-Min;Chen, Ruey-Hwa
通讯作者：
Chen, Ruey-Hwa
影响因子：
4.8
作者：
Kim, Ha Won;Haider, Husnain K.;Ashraf, Muhammad
通讯作者：
Ashraf, Muhammad