Etiology of nursing caries: A microbiologic perspective
Etiology of nursing caries: A microbiologic perspective
复制标题
DOI：
10.1111/j.1752-7325.1996.tb02395.x
复制
发表时间：
1996-12-01
影响因子：
2.3
通讯作者：
Berkowitz, R
中科院分区：
文献类型：
--
作者：
Berkowitz, R
一个令人信服的科学证据支持的概念，护理龋齿是一种传染性和传播性疾病。这一证据有力地支持了这样一个原则，即被变形链球菌定殖的婴儿，以及具有以频繁和长期口腔暴露于致龋基质为特征的喂养习惯的婴儿，其口腔变形链球菌种群可能急剧增加。这种增加与猖獗的龋齿的高风险有关。这一证据有力地表明，在护理龋齿的病因学的第一步是由变形链球菌的原发感染;第二步是这些生物体的积累，致病水平的结果，频繁和长期的口腔暴露于致龋基质;和第三步是快速脱矿质和牙釉质的空化导致猖獗的龋齿。这三个步骤的模式可能会提供一个重要的框架设计的临床试验，以预防护理龋。
A compelling body of scientific evidence supports the concept that nursing caries is an infectious and transmissible disease. This evidence makes a strong case to support the tenet that infants who are colonized by mutans streptococci, and who have feeding habits characterized by frequent and prolonged oral exposure to cariogenic substrates, are likely to have a drastic increase in their oral mutans streptococci populations. Such an increase is associated with a high risk for rampant dental caries. This evidence strongly suggests that the first step in the etiology of nursing caries is primary infection by mutans streptococci; the second step is accumulation of these organisms to pathogenic levels as a consequence of frequent and prolonged oral exposure to cariogenic substrates; and the third step is rapid demineralization and cavitation of enamel resulting in rampant dental caries. This three-step model might provide an important framework for the design of clinical trials targeted at prevention of nursing caries.