Gentisides A and B, two new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch
Gentisides A and B, two new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch
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龙胆甙 A 和 B，是中药龙胆中的两种新的致神经炎化合物
DOI：
10.1016/j.bmc.2010.02.004
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发表时间：
2010-03-15
影响因子：
3.5
通讯作者：
Qi, Jianhua
中科院分区：
文献类型：
--
作者：
Gao, Lijuan;Li, Jinyou;Qi, Jianhua
从中药滇龙胆（Gentiana rigescens Franch）中分离得到两个新的2，3-二羟基苯甲酸烷基酯化合物，即龙胆苷A和B。通过光谱法和化学衍生化方法确定了它们的结构和立体化学。这些化合物在30 μ M时对PC 12细胞显示出显著的神经生活性，这与最佳神经生长因子（NGF）浓度40 ng/mL时所见的活性相当。龙胆苷A和B表现出平行的活性，表明在其烷基链末端观察到的结构差异并不影响神经突活性。(C)2010爱思唯尔有限公司版权所有。
Two new alkyl 2,3-dihydroxybenzoates, gentisides A and B, were isolated from the traditional Chinese medicine Gentiana rigescens Franch. Their structures and stereochemistry were elucidated by spectroscopic methods and chemical derivatization. These compounds showed a significant neuritogenic activity at 30 mu M against PC12 cells that was comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. Gentisides A and B showed parallel activity, indicating that the observed structural difference at the end of their alkyl chain did not affect neuritogenic activity. (C) 2010 Elsevier Ltd. All rights reserved.